C5orf34: Difference between revisions
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'''C5orf34 (chromosome 5 open reading frame 34)''' is a protein that in humans is encoded by the ''C5orf34'' gene (5p12). |
'''C5orf34 (chromosome 5 open reading frame 34)''' is a protein that in humans is encoded by the ''C5orf34'' gene (5p12).<ref>{{Cite web|title = NCBI Protein|url = http://www.ncbi.nlm.nih.gov/protein/Q96MH7.2|website = www.ncbi.nlm.nih.gov|accessdate = 2015-05-09}}</ref><ref>{{Cite web|title = NCBI Gene|url = http://www.ncbi.nlm.nih.gov/gene/375444|website = www.ncbi.nlm.nih.gov|accessdate = 2015-05-09}}</ref> |
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C5orf34 is conserved in mammals, birds and reptiles with the most distant ancestor being the Burmese python, ''Python bivittatus''. The C5orf34 protein contains two mammalian conserved domains: DUF 4520 and DUF 4524. The protein is also predicted to have a Polo-box domain (PBD) of [[polo-like kinase 4]], which has predicted conservation in distant orthologs from the clade Aves.<ref>{{Cite web|title = NCBI Blast|url = http://blast.ncbi.nlm.nih.gov/Blast.cgi|website = www.ncbi.nlm.nih.gov|accessdate = 2015-05-09}}</ref><ref>{{Cite journal|title = Polo-like kinase 4: the odd one out of the family|url = http://www.celldiv.com/content/5/1/25/abstract|journal = Cell Division|date = 2010-09-29|access-date = 2015-05-09|issn = 1747-1028|pmid = 20920249|pages = 25|volume = 5|issue = 1|doi = 10.1186/1747-1028-5-25|language = en|first = James E.|last = Sillibourne|first2 = Michel|last2 = Bornens}}</ref> |
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The ''C5orf34'' gene is located on the short (p) arm of chromosome 5 open reading frame 34, from base pair 43,486,701 to base pair 43,515,445. Its cytogenetic location is at 5p12. The mRNA has 2540 base pairs and the protein has 638 amino acids apart of the master chain region.<ref>http://www.genecards.org/cgi-bin/carddisp.pl?gene=C5orf34</ref> |
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== Gene == |
== Gene == |
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Revision as of 16:14, 9 May 2015
This sandbox is in the article namespace. Either move this page into your userspace, or remove the {{User sandbox}} template. C5orf34 (chromosome 5 open reading frame 34) is a protein that in humans is encoded by the C5orf34 gene (5p12).[1][2]
C5orf34 is conserved in mammals, birds and reptiles with the most distant ancestor being the Burmese python, Python bivittatus. The C5orf34 protein contains two mammalian conserved domains: DUF 4520 and DUF 4524. The protein is also predicted to have a Polo-box domain (PBD) of polo-like kinase 4, which has predicted conservation in distant orthologs from the clade Aves.[3][4]
Gene
C5orf34 is located on the negative DNA strand of the short arm of chromosome 6 at locus 12. The gene is 2,540 base pairs long and spans from base pair 43,486,701 to base pair 43,515,445.
Expression
Protein
C5orf34 consists of 638 amino acids, has a weight of 72.7 kDa and an isolelectric point of 7.77 in humans.
Function
Post-translational Modification
There is strong evidence to support that there is phosphorylation of C5orf34 at its serine sites (32 in particular). The protein is also predicted to be confined to just the nucleus at a 92% confidence level.
Secondary Structure
Interacting Proteins
It has been predicted that C5orf34 interacts with ubiquitin C (UBC) per experimental support via the STRING database.
Homology
C5orf34 is highly conserved in primates and mammals and moderately conserved in reptiles. The furtherest conserved ortholog is in Python bivittatus, or the Burmese python. Below is a selected list of orthologs to demonstrate the homology of this gene with relation to the reference sequence in Homo sapiens.
Conserved Domains
The C5orf34 protein has two conserved domains of unknown function, DUF 4520 (pfam 15016) and DUF 4524 (pfam 150125). The N-terminal domain, DUF4524, covers from amino acid 6 to 153 and the C-terminal domain, DUF 4520, covers from amino acid 445 to 539.
Clinical Significance
References
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- ^ "NCBI Protein". www.ncbi.nlm.nih.gov. Retrieved 2015-05-09.
- ^ "NCBI Gene". www.ncbi.nlm.nih.gov. Retrieved 2015-05-09.
- ^ "NCBI Blast". www.ncbi.nlm.nih.gov. Retrieved 2015-05-09.
- ^ Sillibourne, James E.; Bornens, Michel (2010-09-29). "Polo-like kinase 4: the odd one out of the family". Cell Division. 5 (1): 25. doi:10.1186/1747-1028-5-25. ISSN 1747-1028. PMID 20920249. Retrieved 2015-05-09.
{{cite journal}}: CS1 maint: unflagged free DOI (link)