OMA1: Difference between revisions

OMA1
Identifiers
Aliases	OMA1, 2010001O09Rik, DAB1, MPRP-1, YKR087C, ZMPpeptidase, OMA1 zinc metallopeptidase, MPRP1
External IDs	OMIM: 617081; MGI: 1914263; HomoloGene: 12070; GeneCards: OMA1; OMA:OMA1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	58,546,802 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	103,229,065 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; Achilles tendon; ; bone marrow cells; ; right uterine tube; ; corpus callosum; ; caput epididymis; ; renal medulla; ; right adrenal gland; ; superior surface of tongue; ; rectum;
	Top expressed in
	interventricular septum; ; right ventricle; ; myocardium of ventricle; ; sternocleidomastoid muscle; ; digastric muscle; ; temporal muscle; ; epithelium of stomach; ; vastus lateralis muscle; ; tibialis anterior muscle; ; extraocular muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity;
Cellular component	membrane; integral component of membrane; mitochondrial membranes; mitochondrion; mitochondrial inner membrane;
Biological process	mitochondrial protein processing; energy homeostasis; response to stress; mitochondrion organization; cristae formation; protein quality control for misfolded or incompletely synthesized proteins; negative regulation of mitochondrial fusion; proteolysis; lipid metabolism; glucose metabolic process; diet induced thermogenesis; regulation of apoptotic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	115209
	67013
	ENSG00000162600
	ENSMUSG00000035069
	Q96E52
	Q9D8H7
	NM_145243
	NM_025909
	NP_660286
	NP_080185
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 17:27, 15 May 2015

Metalloendopeptidase OMA1, mitochondrial is an enzyme that in humans is encoded by the OMA1 gene.^[5] As a Metalloprotease, this protein is a substantial component of the quality control system in the inner membrane of mitochondria. Being activated by enzyme Bax and Bak, mitochondrial protease OMA1 promotes cytochrome c release which subsequently induces apoptosis^[6].

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162600 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035069 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: OMA1 zinc metallopeptidase".
^ Jiang, X; Jiang, H; Shen, Z; Wang, X (14 October 2014). "Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 111 (41): 14782–7. PMID 25275009.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162600 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035069 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OMA1 zinc metallopeptidase".

[6] Jiang, X; Jiang, H; Shen, Z; Wang, X (14 October 2014). "Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 111 (41): 14782–7. PMID 25275009.

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