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'''LanC-like protein 2''' is a [[protein]] that in humans is encoded by the ''LANCL2'' [[gene]].<ref name="pmid11762191">{{cite journal | author = Mayer H, Pongratz M, Prohaska R | title = Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family | journal = DNA Seq | volume = 12 | issue = 3 | pages = 161–6 |date=Dec 2001 | pmid = 11762191 | pmc = | doi = 10.3109/10425170109080770}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55915| accessdate = }}</ref> |
'''LanC-like protein 2''' is a [[protein]] that in humans is encoded by the ''LANCL2'' [[gene]].<ref name="pmid11762191">{{cite journal | author = Mayer H, Pongratz M, Prohaska R | title = Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family | journal = DNA Seq | volume = 12 | issue = 3 | pages = 161–6 |date=Dec 2001 | pmid = 11762191 | pmc = | doi = 10.3109/10425170109080770}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55915| accessdate = }}</ref> It is a protein broadly expressed in the plasma an nuclear membranes of immune, epithelial and muscle cells and a potential therapeutic target for chronic inflammatory, metabolic and immune-mediated diseases such as [[Crohn's disease|Crohn’s disease]] and diabetes.<ref>{{Cite journal|title = Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes|url = http://www.ncbi.nlm.nih.gov/pubmed/24628287|journal = Current Drug Targets|date = 2014-06-01|issn = 1873-5592|pmid = 24628287|pages = 565–572|volume = 15|issue = 6|first = Pinyi|last = Lu|first2 = Raquel|last2 = Hontecillas|first3 = Casandra W.|last3 = Philipson|first4 = Josep|last4 = Bassaganya-Riera}}</ref> |
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The natural ligand of [[LANCL2]], [[abscisic acid]] (ABA), has been identified as a new endogenous mammalian hormone implicated in glycemic control. The mammalian ABA receptor has been identified as LANCL2 on the basis of: |
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1) modeling predictions <ref>{{Cite journal|title = Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics|url = http://www.ncbi.nlm.nih.gov/pubmed/20512604|journal = Journal of Molecular Modeling|date = 2011-03-01|issn = 0948-5023|pmid = 20512604|pages = 543–553|volume = 17|issue = 3|doi = 10.1007/s00894-010-0748-y|first = Pinyi|last = Lu|first2 = David R.|last2 = Bevan|first3 = Stephanie N.|last3 = Lewis|first4 = Raquel|last4 = Hontecillas|first5 = Josep|last5 = Bassaganya-Riera}}</ref> |
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2) direct and specific ABA binding to the purified recombinant protein <ref>{{Cite journal|title = Binding of abscisic acid to human LANCL2|url = http://www.ncbi.nlm.nih.gov/pubmed/22037458|journal = Biochemical and Biophysical Research Communications|date = 2011-11-18|issn = 1090-2104|pmid = 22037458|pages = 390–395|volume = 415|issue = 2|doi = 10.1016/j.bbrc.2011.10.079|first = Laura|last = Sturla|first2 = Chiara|last2 = Fresia|first3 = Lucrezia|last3 = Guida|first4 = Alessia|last4 = Grozio|first5 = Tiziana|last5 = Vigliarolo|first6 = Elena|last6 = Mannino|first7 = Enrico|last7 = Millo|first8 = Luca|last8 = Bagnasco|first9 = Santina|last9 = Bruzzone}}</ref>, and |
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3) abrogation of the functional effects of ABA by silencing of LANCL2 expression in ABA-sensitive cells. <ref>{{Cite journal|title = LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells|url = http://www.ncbi.nlm.nih.gov/pubmed/19667068|journal = The Journal of Biological Chemistry|date = 2009-10-09|issn = 1083-351X|pmc = 2788856|pmid = 19667068|pages = 28045–28057|volume = 284|issue = 41|doi = 10.1074/jbc.M109.035329|first = Laura|last = Sturla|first2 = Chiara|last2 = Fresia|first3 = Lucrezia|last3 = Guida|first4 = Santina|last4 = Bruzzone|first5 = Sonia|last5 = Scarfì|first6 = Cesare|last6 = Usai|first7 = Floriana|last7 = Fruscione|first8 = Mirko|last8 = Magnone|first9 = Enrico|last9 = Millo}}</ref> <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> |
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Revision as of 05:39, 9 February 2016
Template:PBB LanC-like protein 2 is a protein that in humans is encoded by the LANCL2 gene.[1][2] It is a protein broadly expressed in the plasma an nuclear membranes of immune, epithelial and muscle cells and a potential therapeutic target for chronic inflammatory, metabolic and immune-mediated diseases such as Crohn’s disease and diabetes.[3]
The natural ligand of LANCL2, abscisic acid (ABA), has been identified as a new endogenous mammalian hormone implicated in glycemic control. The mammalian ABA receptor has been identified as LANCL2 on the basis of:
1) modeling predictions [4]
2) direct and specific ABA binding to the purified recombinant protein [5], and
3) abrogation of the functional effects of ABA by silencing of LANCL2 expression in ABA-sensitive cells. [6]
References
- ^ Mayer H, Pongratz M, Prohaska R (Dec 2001). "Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family". DNA Seq. 12 (3): 161–6. doi:10.3109/10425170109080770. PMID 11762191.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)".
- ^ Lu, Pinyi; Hontecillas, Raquel; Philipson, Casandra W.; Bassaganya-Riera, Josep (2014-06-01). "Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes". Current Drug Targets. 15 (6): 565–572. ISSN 1873-5592. PMID 24628287.
- ^ Lu, Pinyi; Bevan, David R.; Lewis, Stephanie N.; Hontecillas, Raquel; Bassaganya-Riera, Josep (2011-03-01). "Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics". Journal of Molecular Modeling. 17 (3): 543–553. doi:10.1007/s00894-010-0748-y. ISSN 0948-5023. PMID 20512604.
- ^ Sturla, Laura; Fresia, Chiara; Guida, Lucrezia; Grozio, Alessia; Vigliarolo, Tiziana; Mannino, Elena; Millo, Enrico; Bagnasco, Luca; Bruzzone, Santina (2011-11-18). "Binding of abscisic acid to human LANCL2". Biochemical and Biophysical Research Communications. 415 (2): 390–395. doi:10.1016/j.bbrc.2011.10.079. ISSN 1090-2104. PMID 22037458.
- ^ Sturla, Laura; Fresia, Chiara; Guida, Lucrezia; Bruzzone, Santina; Scarfì, Sonia; Usai, Cesare; Fruscione, Floriana; Magnone, Mirko; Millo, Enrico (2009-10-09). "LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells". The Journal of Biological Chemistry. 284 (41): 28045–28057. doi:10.1074/jbc.M109.035329. ISSN 1083-351X. PMC 2788856. PMID 19667068.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
Further reading
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