Lactate dehydrogenase b

LDHB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I0Z, 1T2F
Identifiers
Aliases	LDHB, HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5, lactate dehydrogenase B
External IDs	OMIM: 150100; MGI: 96763; HomoloGene: 55647; GeneCards: LDHB; OMA:LDHB - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p12.1 Start 21,635,342 bp End 21,757,857 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 G2|6 74.17 cM Start 142,435,975 bp End 142,453,683 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla right ventricle external globus pallidus endothelial cell kidney tubule middle temporal gyrus pons superior vestibular nucleus kidney Brodmann area 23 Top expressed in secondary oocyte right ventricle superior frontal gyrus anterior horn of spinal cord proximal tubule facial motor nucleus utricle cardiac muscles cerebellar cortex pontine nuclei More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity lactate dehydrogenase activity protein binding kinase binding NAD binding catalytic activity L-lactate dehydrogenase activity identical protein binding Cellular component extracellular exosome membrane raft membrane myelin sheath mitochondrion cytoplasm cytosol Biological process NAD metabolic process lactate metabolic process carboxylic acid metabolic process pyruvate metabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3945 16832 Ensembl ENSG00000111716 ENSMUSG00000030246 UniProt P07195 P16125 RefSeq (mRNA) NM_001174097 NM_002300 NM_001315537 NM_008492 NM_001302765 NM_001316322 RefSeq (protein) NP_001167568 NP_001302466 NP_002291 NP_001289694 NP_001303251 NP_032518 Location (UCSC) Chr 12: 21.64 – 21.76 Mb Chr 6: 142.44 – 142.45 Mb PubMed search
Wikidata
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Lactate dehydrogenase B is a protein that in humans is encoded by the LDHB gene.

Function

This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13.

Further reading

• Philibert RA, Nelson JJ, Sandhu HK, Crowe RR, Coryell WH (2003). "Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder". Am. J. Med. Genet. B Neuropsychiatr. Genet. 117B (1): 11–7. doi:10.1002/ajmg.b.10015. PMID 12555229.
• Mazzotta S, Guerranti R, Gozzetti A, Bucalossi A, Bocchia M, Sammassimo S, Petralia S, Ogueli GI, Lauria F (2006). "Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation?". Hematology. 11 (4): 239–44. doi:10.1080/10245330600774835. PMID 17178662.
• de Haas T, Hasselt N, Troost D, Caron H, Popovic M, Zadravec-Zaletel L, Grajkowska W, Perek M, Osterheld MC, Ellison D, Baas F, Versteeg R, Kool M (2008). "Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression". Clin. Cancer Res. 14 (13): 4154–60. doi:10.1158/1078-0432.CCR-07-4159. PMID 18593994.
• Whyte MP, Kempa LG, McAlister WH, Zhang F, Mumm S, Wenkert D (2010). "Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders". J. Bone Miner. Res. 25 (11): 2515–26. doi:10.1002/jbmr.130. PMID 20499337.
• Egberts F, Momkvist A, Egberts JH, Kaehler KC, Hauschild A (2010). "Serum S100B and LDH are not useful in predicting the sentinel node status in melanoma patients". Anticancer Res. 30 (5): 1799–805. PMID 20592382.
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLoS ONE. 5 (9): e12862. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Swiderek K, Paneth P (2011). "Differences and similarities in binding of pyruvate and L-lactate in the active site of M4 and H4 isoforms of human lactate dehydrogenase". Arch. Biochem. Biophys. 505 (1): 33–41. doi:10.1016/j.abb.2010.10.010. PMID 20951115.
• Zha X, Wang F, Wang Y, He S, Jing Y, Wu X, Zhang H (2011). "Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis". Cancer Res. 71 (1): 13–8. doi:10.1158/0008-5472.CAN-10-1668. PMID 21199794.
• Kim JH, Kim EL, Lee YK, Park CB, Kim BW, Wang HJ, Yoon CH, Lee SJ, Yoon G (2011). "Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects". Exp. Cell Res. 317 (8): 1108–18. doi:10.1016/j.yexcr.2011.02.011. PMID 21356207.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.