XRN1 (gene): Difference between revisions
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'''5'-3' exoribonuclease 1''' ('''Xrn1''') is a [[protein]] that in humans is encoded by the XRN1 [[gene]]. Xrn1 [[Hydrolysis|hydrolyses]] [[RNA]] in the 5’ to 3’ direction.<ref>{{cite journal|last1=Mullen|first1=T. E.|last2=Marzluff|first2=W. F.|title=Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'|journal=Genes & Development|date=1 January 2008|volume=22|issue=1|pages=50–65|doi=10.1101/gad.1622708|url=http://genesdev.cshlp.org/content/22/1/50.full|pmid=18172165|pmc=2151014}}</ref> |
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'''5'-3' exoribonuclease 1''' is a [[protein]] that in humans is encoded by the XRN1 [[gene]]. |
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Revision as of 06:59, 19 January 2018
5'-3' exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. Xrn1 hydrolyses RNA in the 5’ to 3’ direction.[5] [6]
Function
This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000114127 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032410 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mullen, T. E.; Marzluff, W. F. (1 January 2008). "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'". Genes & Development. 22 (1): 50–65. doi:10.1101/gad.1622708. PMC 2151014. PMID 18172165.
- ^ "Entrez Gene: 5'-3' exoribonuclease 1". Retrieved 2018-01-19.
Further reading
- Bashkirov VI, Scherthan H, Solinger JA, Buerstedde JM, Heyer WD (1997). "A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates". J. Cell Biol. 136 (4): 761–73. PMC 2132493. PMID 9049243.
- Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. PMC 1370355. PMID 12515382.
- Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M, Izaurralde E (2012). "A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation". Nat. Struct. Mol. Biol. 19 (12): 1324–31. doi:10.1038/nsmb.2413. PMID 23142987.
- Li Y, Masaki T, Yamane D, McGivern DR, Lemon SM (2013). "Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication". Proc. Natl. Acad. Sci. U.S.A. 110 (5): 1881–6. doi:10.1073/pnas.1213515110. PMC 3562843. PMID 23248316.
- Li Y, Yamane D, Lemon SM (2015). "Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication". J. Virol. 89 (9): 4857–65. doi:10.1128/JVI.03692-14. PMC 4403451. PMID 25673723.
- Burgess HM, Mohr I (2015). "Cellular 5'-3' mRNA exonuclease Xrn1 controls double-stranded RNA accumulation and anti-viral responses". Cell Host Microbe. 17 (3): 332–44. doi:10.1016/j.chom.2015.02.003. PMC 4826345. PMID 25766294.
- Ding M, Lin B, Li T, Liu Y, Li Y, Zhou X, Miao M, Gu J, Pan H, Yang F, Li T, Liu XY, Li R (2015). "A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells". Oncotarget. 6 (10): 7686–700. doi:10.18632/oncotarget.3480. PMC 4480709. PMID 25797256.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.