Harmol: Difference between revisions
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'''Harmol''' is a [[β-carboline]] isolated from nature.<ref name="pmid23338618">{{cite journal|vauthors=Abe A, Kokuba H | title=Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of survivin. | journal=Oncol Rep | year= 2013 | volume= 29 | issue= 4 | pages= 1333–42 | pmid=23338618 | doi=10.3892/or.2013.2242 | pmc= | url=https://www.ncbi.nlm.nih.gov/pubmed/23338618 }}</ref><ref name="pmid22001777">{{cite journal|vauthors=El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO | title=Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol. | journal=Toxicol Lett | year= 2012 | volume= 208 | issue= 1 | pages= 51–61 | pmid=22001777 | doi=10.1016/j.toxlet.2011.09.030 | pmc=3263333 }}</ref><ref name="pmid21804216">{{cite journal|vauthors=Abe A, Yamada H, Moriya S, Miyazawa K | title=The β-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells. | journal=Biol Pharm Bull | year= 2011 | volume= 34 | issue= 8 | pages= 1264–72 | pmid=21804216 | doi= 10.1248/bpb.34.1264| pmc= | url=https://www.ncbi.nlm.nih.gov/pubmed/21804216 }}</ref> |
'''Harmol''' is a [[β-carboline]] isolated from nature. <ref name="pmid23338618">{{cite journal|vauthors=Abe A, Kokuba H | title=Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of survivin. | journal=Oncol Rep | year= 2013 | volume= 29 | issue= 4 | pages= 1333–42 | pmid=23338618 | doi=10.3892/or.2013.2242 | pmc= | url=https://www.ncbi.nlm.nih.gov/pubmed/23338618 }}</ref><ref name="pmid22001777">{{cite journal|vauthors=El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO | title=Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol. | journal=Toxicol Lett | year= 2012 | volume= 208 | issue= 1 | pages= 51–61 | pmid=22001777 | doi=10.1016/j.toxlet.2011.09.030 | pmc=3263333 }}</ref><ref name="pmid21804216">{{cite journal|vauthors=Abe A, Yamada H, Moriya S, Miyazawa K | title=The β-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells. | journal=Biol Pharm Bull | year= 2011 | volume= 34 | issue= 8 | pages= 1264–72 | pmid=21804216 | doi= 10.1248/bpb.34.1264| pmc= | url=https://www.ncbi.nlm.nih.gov/pubmed/21804216 }}</ref> It is readily formed in vivo in humans by O-demethylation of [[harmine]]. <ref name="pmid28706205">{{cite journal|vauthors=Morales-Garcia JA, de la Fuenta Revenga M, Alonso-Gil S, Rodriguez-Franco MI, Feiding A, Perez-Castillo A, Riba J | title=The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro. | journal=Sci. Rep | year=2017 | pmid=28706205 | doi=10.1038/s41598-017-05407-9 | url=https://www.ncbi.nlm.nih.gov/pubmed/28706205 }}</ref> |
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==References== |
==References== |
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Revision as of 15:48, 24 January 2018
 | This article needs more links to other articles to help integrate it into the encyclopedia. (December 2015) |
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| Names | |
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| IUPAC name
1-methyl-2,9-dihydropyrido[3,4-b]indol-7-one
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| ECHA InfoCard | 100.006.951 |
PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C12H10N2O | |
| Molar mass | 198.22 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Harmol is a β-carboline isolated from nature. [1][2][3] It is readily formed in vivo in humans by O-demethylation of harmine. [4]
References
- ^ Abe A, Kokuba H (2013). "Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of survivin". Oncol Rep. 29 (4): 1333–42. doi:10.3892/or.2013.2242. PMID 23338618.
- ^ El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO (2012). "Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol". Toxicol Lett. 208 (1): 51–61. doi:10.1016/j.toxlet.2011.09.030. PMC 3263333. PMID 22001777.
- ^ Abe A, Yamada H, Moriya S, Miyazawa K (2011). "The β-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells". Biol Pharm Bull. 34 (8): 1264–72. doi:10.1248/bpb.34.1264. PMID 21804216.
- ^ Morales-Garcia JA, de la Fuenta Revenga M, Alonso-Gil S, Rodriguez-Franco MI, Feiding A, Perez-Castillo A, Riba J (2017). "The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro". Sci. Rep. doi:10.1038/s41598-017-05407-9. PMID 28706205.
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