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{{other uses|Marco (disambiguation)}}
{{other uses|Marco (disambiguation)}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Macrophage receptor MARCO''' also known as '''macrophage receptor with collagenous structure''' (MARCO) is a [[protein]] that in humans is encoded by the ''MARCO'' [[gene]].<ref name="pmid9468508">{{cite journal | vauthors = Elomaa O, Sankala M, Pikkarainen T, Bergmann U, Tuuttila A, Raatikainen-Ahokas A, Sariola H, Tryggvason K | title = Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region | journal = The Journal of Biological Chemistry | volume = 273 | issue = 8 | pages = 4530–8 | date = February 1998 | pmid = 9468508 | doi = 10.1074/jbc.273.8.4530 }}</ref><ref name="pmid7867067">{{cite journal | vauthors = Elomaa O, Kangas M, Sahlberg C, Tuukkanen J, Sormunen R, Liakka A, Thesleff I, Kraal G, Tryggvason K | title = Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages | journal = Cell | volume = 80 | issue = 4 | pages = 603–9 | date = February 1995 | pmid = 7867067 | pmc = | doi = 10.1016/0092-8674(95)90514-6 }}</ref><ref name="pmid10331948">{{cite journal | vauthors = Kangas M, Brännström A, Elomaa O, Matsuda Y, Eddy R, Shows TB, Tryggvason K | title = Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor | journal = Genomics | volume = 58 | issue = 1 | pages = 82–9 | date = May 1999 | pmid = 10331948 | pmc = | doi = 10.1006/geno.1999.5811 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MARCO macrophage receptor with collagenous structure| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8685| accessdate = }}</ref>
'''Macrophage receptor MARCO''' also known as '''macrophage receptor with collagenous structure''' (MARCO) is a [[protein]] that in humans is encoded by the ''MARCO'' [[gene]].<ref name="pmid9468508">{{cite journal | vauthors = Elomaa O, Sankala M, Pikkarainen T, Bergmann U, Tuuttila A, Raatikainen-Ahokas A, Sariola H, Tryggvason K | title = Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region | journal = The Journal of Biological Chemistry | volume = 273 | issue = 8 | pages = 4530–8 | date = February 1998 | pmid = 9468508 | doi = 10.1074/jbc.273.8.4530 }}</ref><ref name="pmid7867067">{{cite journal | vauthors = Elomaa O, Kangas M, Sahlberg C, Tuukkanen J, Sormunen R, Liakka A, Thesleff I, Kraal G, Tryggvason K | title = Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages | journal = Cell | volume = 80 | issue = 4 | pages = 603–9 | date = February 1995 | pmid = 7867067 | pmc = | doi = 10.1016/0092-8674(95)90514-6 }}</ref><ref name="pmid10331948">{{cite journal | vauthors = Kangas M, Brännström A, Elomaa O, Matsuda Y, Eddy R, Shows TB, Tryggvason K | title = Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor | journal = Genomics | volume = 58 | issue = 1 | pages = 82–9 | date = May 1999 | pmid = 10331948 | pmc = | doi = 10.1006/geno.1999.5811 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MARCO macrophage receptor with collagenous structure| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8685| accessdate = }}</ref> MARCO is a class A [[Scavenger receptor (immunology)|scavenger receptor]] that is found on particular subsets of macrophages.<ref name=":1">{{Cite journal|last=Plüddemann|first=Annette|last2=Neyen|first2=Claudine|last3=Gordon|first3=Siamon|title=Macrophage scavenger receptors and host-derived ligands|url=http://linkinghub.elsevier.com/retrieve/pii/S1046202307001296|journal=Methods|volume=43|issue=3|pages=207–217|doi=10.1016/j.ymeth.2007.06.004}}</ref><ref name=":0">{{Cite journal|last=Bowdish|first=Dawn M. E.|last2=Gordon|first2=Siamon|date=2009-01-01|title=Conserved domains of the class A scavenger receptors: evolution and function|url=http://onlinelibrary.wiley.com/doi/10.1111/j.1600-065X.2008.00728.x/abstract|journal=Immunological Reviews|language=en|volume=227|issue=1|pages=19–31|doi=10.1111/j.1600-065x.2008.00728.x|issn=1600-065X}}</ref><ref name=":5">{{Cite journal|last=Mukhopadhyay|first=Subhankar|last2=Varin|first2=Audrey|last3=Chen|first3=Yunying|last4=Liu|first4=Baoying|last5=Tryggvason|first5=Karl|last6=Gordon|first6=Siamon|date=2011-01-27|title=SR-A/MARCO–mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens|url=http://www.bloodjournal.org/content/117/4/1319|journal=Blood|language=en|volume=117|issue=4|pages=1319–1328|doi=10.1182/blood-2010-03-276733|issn=0006-4971|pmid=21098741}}</ref> Scavenger receptors are [[Pattern recognition receptor|pattern recognition receptors]] (PRRs) and are most commonly found on immune cells.<ref name=":0" /> Their defining feature is that they bind to polyanions and modified forms of a type of cholesterol called low-density lipoprotein ([[Low-density lipoprotein|LDL]]).<ref name=":1" /><ref name=":0" /> MARCO is able to bind and phagocytose these ligands and pathogen-associated molecular patterns ([[PAMPs]]), leading to the clearance of pathogens as well as causing downstream effects in the cell that lead to inflammation.<ref name=":5" /><ref name=":3">{{Cite journal|last=Novakowski|first=Kyle E|last2=Huynh|first2=Angela|last3=Han|first3=SeongJun|last4=Dorrington|first4=Michael G|last5=Yin|first5=Charles|last6=Tu|first6=Zhongyuan|last7=Pelka|first7=Peter|last8=Whyte|first8=Peter|last9=Guarné|first9=Alba|date=2016-08-01|title=A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function|url=http://onlinelibrary.wiley.com/doi/10.1038/icb.2016.20/abstract|journal=Immunology and Cell Biology|language=en|volume=94|issue=7|pages=646–655|doi=10.1038/icb.2016.20|issn=1440-1711}}</ref> As part of the innate immune system, MARCO clears, or scavenges, pathogens and leads to inflammatory responses.<ref name=":3" /> The scavenger receptor cysteine-rich (SRCR) domain at the end of the extracellular side of MARCO is responsible for ligand binding and the subsequent immune responses.<ref name=":3" /> Increased MARCO expression on macrophages is also associated with diseases such as prostate and liver cancer, and Alzheimer's disease is associated with decreased response within the cell when a ligand binds to MARCO.<ref name=":6">{{Cite journal|last=Sun|first=Haoyu|last2=Song|first2=Jiaxi|last3=Weng|first3=Chenchun|last4=Xu|first4=Jing|last5=Huang|first5=Mei|last6=Huang|first6=Qiang|last7=Sun|first7=Rui|last8=Xiao|first8=Weihua|last9=Sun|first9=Cheng|date=2017-05-01|title=Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma|url=http://onlinelibrary.wiley.com/doi/10.1111/jgh.13633/abstract|journal=Journal of Gastroenterology and Hepatology|language=en|volume=32|issue=5|pages=1107–1114|doi=10.1111/jgh.13633|issn=1440-1746}}</ref><ref name=":4">{{Cite journal|last=Yu|first=Yang|last2=Ye|first2=Richard D.|date=2015-01-01|title=Microglial Aβ Receptors in Alzheimer’s Disease|url=https://link.springer.com/article/10.1007/s10571-014-0101-6|journal=Cellular and Molecular Neurobiology|language=en|volume=35|issue=1|pages=71–83|doi=10.1007/s10571-014-0101-6|issn=0272-4340}}</ref>


== Function ==
== Function ==

Revision as of 03:20, 28 February 2018

For other uses, see Marco (disambiguation).
MARCO
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMARCO, SCARA2, macrophage receptor with collagenous structure, SR-A6
External IDsOMIM: 604870 MGI: 1309998 HomoloGene: 4928 GeneCards: MARCO
Orthologs
SpeciesHumanMouse
Entrez

8685

17167

Ensembl

ENSG00000019169

ENSMUSG00000026390

UniProt

Q9UEW3

Q60754

RefSeq (mRNA)

NM_006770

NM_010766

RefSeq (protein)

NP_006761

NP_034896

Location (UCSC)Chr 2: 118.94 – 118.99 MbChr 1: 120.4 – 120.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Macrophage receptor MARCO also known as macrophage receptor with collagenous structure (MARCO) is a protein that in humans is encoded by the MARCO gene.[5][6][7][8] MARCO is a class A scavenger receptor that is found on particular subsets of macrophages.[9][10][11] Scavenger receptors are pattern recognition receptors (PRRs) and are most commonly found on immune cells.[10] Their defining feature is that they bind to polyanions and modified forms of a type of cholesterol called low-density lipoprotein (LDL).[9][10] MARCO is able to bind and phagocytose these ligands and pathogen-associated molecular patterns (PAMPs), leading to the clearance of pathogens as well as causing downstream effects in the cell that lead to inflammation.[11][12] As part of the innate immune system, MARCO clears, or scavenges, pathogens and leads to inflammatory responses.[12] The scavenger receptor cysteine-rich (SRCR) domain at the end of the extracellular side of MARCO is responsible for ligand binding and the subsequent immune responses.[12] Increased MARCO expression on macrophages is also associated with diseases such as prostate and liver cancer, and Alzheimer's disease is associated with decreased response within the cell when a ligand binds to MARCO.[13][14]

Function

MARCO protein levels also decrease in hepatocellular carcinoma (HCC). Macrophages within the tumors of people with metastatic HCC have a lower expression of MARCO than those found in the tissues surrounding the tumor.[15]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000019169 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026390 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Elomaa O, Sankala M, Pikkarainen T, Bergmann U, Tuuttila A, Raatikainen-Ahokas A, Sariola H, Tryggvason K (February 1998). "Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region". The Journal of Biological Chemistry. 273 (8): 4530–8. doi:10.1074/jbc.273.8.4530. PMID 9468508.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  6. ^ Elomaa O, Kangas M, Sahlberg C, Tuukkanen J, Sormunen R, Liakka A, Thesleff I, Kraal G, Tryggvason K (February 1995). "Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages". Cell. 80 (4): 603–9. doi:10.1016/0092-8674(95)90514-6. PMID 7867067.
  7. ^ Kangas M, Brännström A, Elomaa O, Matsuda Y, Eddy R, Shows TB, Tryggvason K (May 1999). "Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor". Genomics. 58 (1): 82–9. doi:10.1006/geno.1999.5811. PMID 10331948.
  8. ^ "Entrez Gene: MARCO macrophage receptor with collagenous structure".
  9. ^ a b Plüddemann, Annette; Neyen, Claudine; Gordon, Siamon. "Macrophage scavenger receptors and host-derived ligands". Methods. 43 (3): 207–217. doi:10.1016/j.ymeth.2007.06.004.
  10. ^ a b c Bowdish, Dawn M. E.; Gordon, Siamon (2009-01-01). "Conserved domains of the class A scavenger receptors: evolution and function". Immunological Reviews. 227 (1): 19–31. doi:10.1111/j.1600-065x.2008.00728.x. ISSN 1600-065X.
  11. ^ a b Mukhopadhyay, Subhankar; Varin, Audrey; Chen, Yunying; Liu, Baoying; Tryggvason, Karl; Gordon, Siamon (2011-01-27). "SR-A/MARCO–mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens". Blood. 117 (4): 1319–1328. doi:10.1182/blood-2010-03-276733. ISSN 0006-4971. PMID 21098741.
  12. ^ a b c Novakowski, Kyle E; Huynh, Angela; Han, SeongJun; Dorrington, Michael G; Yin, Charles; Tu, Zhongyuan; Pelka, Peter; Whyte, Peter; Guarné, Alba (2016-08-01). "A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function". Immunology and Cell Biology. 94 (7): 646–655. doi:10.1038/icb.2016.20. ISSN 1440-1711.
  13. ^ Sun, Haoyu; Song, Jiaxi; Weng, Chenchun; Xu, Jing; Huang, Mei; Huang, Qiang; Sun, Rui; Xiao, Weihua; Sun, Cheng (2017-05-01). "Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma". Journal of Gastroenterology and Hepatology. 32 (5): 1107–1114. doi:10.1111/jgh.13633. ISSN 1440-1746.
  14. ^ Yu, Yang; Ye, Richard D. (2015-01-01). "Microglial Aβ Receptors in Alzheimer's Disease". Cellular and Molecular Neurobiology. 35 (1): 71–83. doi:10.1007/s10571-014-0101-6. ISSN 0272-4340.
  15. ^ Sun H, Song J, Weng C, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C (May 2017). "Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma". Journal of Gastroenterology and Hepatology. 32 (5): 1107–1114. doi:10.1111/jgh.13633. PMID 27806438.

Further reading

  • Elshourbagy NA, Li X, Terrett J, Vanhorn S, Gross MS, Adamou JE, Anderson KM, Webb CL, Lysko PG (February 2000). "Molecular characterization of a human scavenger receptor, human MARCO". European Journal of Biochemistry. 267 (3): 919–26. doi:10.1046/j.1432-1327.2000.01077.x. PMID 10651831.
  • Seta N, Granfors K, Sahly H, Kuipers JG, Song YW, Baeten D, Veys EM, Maksymowych W, Märker-Hermann E, Gu J, Huang F, Kirveskari J, Yu DT (April 2001). "Expression of host defense scavenger receptors in spondylarthropathy". Arthritis and Rheumatism. 44 (4): 931–9. doi:10.1002/1529-0131(200104)44:4<931::AID-ANR150>3.0.CO;2-T. PMID 11315932.
  • Brännström A, Sankala M, Tryggvason K, Pikkarainen T (February 2002). "Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO". Biochemical and Biophysical Research Communications. 290 (5): 1462–9. doi:10.1006/bbrc.2002.6378. PMID 11820786.
  • Sankala M, Brännström A, Schulthess T, Bergmann U, Morgunova E, Engel J, Tryggvason K, Pikkarainen T (September 2002). "Characterization of recombinant soluble macrophage scavenger receptor MARCO". The Journal of Biological Chemistry. 277 (36): 33378–85. doi:10.1074/jbc.M204494200. PMID 12097327.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Mirani M, Elenkov I, Volpi S, Hiroi N, Chrousos GP, Kino T (December 2002). "HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection". Journal of Immunology. 169 (11): 6361–8. doi:10.4049/jimmunol.169.11.6361. PMID 12444143.
  • Bin LH, Nielson LD, Liu X, Mason RJ, Shu HB (July 2003). "Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair". Journal of Immunology. 171 (2): 924–30. doi:10.4049/jimmunol.171.2.924. PMID 12847263.
  • Arredouani MS, Palecanda A, Koziel H, Huang YC, Imrich A, Sulahian TH, Ning YY, Yang Z, Pikkarainen T, Sankala M, Vargas SO, Takeya M, Tryggvason K, Kobzik L (November 2005). "MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages". Journal of Immunology. 175 (9): 6058–64. doi:10.4049/jimmunol.175.9.6058. PMID 16237101.
  • Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
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