Arginine alpha-ketoglutarate: Difference between revisions
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'''Arginine ''alpha''-ketoglutarate''' ('''AAKG''') is a [[salt (chemistry)|salt]] of the amino acid [[arginine]] and [[alpha-Ketoglutaric acid|''alpha''-ketoglutaric acid]]. It is marketed as a [[bodybuilding]] supplement. The components are intermediates in the [[metabolism of nitric oxide]]s, but no reputable scientific evidence shows any benefits from taking AAKG as a [[dietary supplement]]. |
'''Arginine ''alpha''-ketoglutarate''' ('''AAKG''') is a [[salt (chemistry)|salt]] of the amino acid [[arginine]] and [[alpha-Ketoglutaric acid|''alpha''-ketoglutaric acid]]. It is marketed as a [[bodybuilding]] supplement. The components are intermediates in the [[metabolism of nitric oxide]]s, but no reputable scientific evidence shows any benefits from taking AAKG as a [[dietary supplement]]. |
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As of 2008, "there [was] no research published in [[Peer review|peer-reviewed]] journals to support the assertion that an increase in nitric oxide levels promotes greater [[muscle]] [[protein synthesis]] or improves muscle strength. There is also no evidence that the arginine alpha-ketoglutarate in nitric oxide supplements have any effect on [[nitric oxide]] levels in muscles."<ref>[http://baye.com/no-supplements-no-way-2/ High Intensity Training by Drew Baye - NO Supplements? No Way!<!-- Bot generated title -->]</ref> |
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A recent study examined the effects of AAKG supplementation on heart rate, blood pressure, blood flow, [[NOx|NO<sub>x</sub>]]/[[nitrogen dioxide|NO<sub>2</sub>]] levels, and [[arginine|<small>L</small>-arginine]] levels. Minimal observed changes were attributed to [[resistance exercise]] used in the experimental design, not to AAKG supplementation, although arginine levels were found to have been elevated.<ref>{{cite journal|last=Willoughby|first=DS|author2=Boucher T|author3=Reid J|author4=Skelton G|author5=Clark M|title=Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise|journal=[[International Journal of Sport Nutrition and Exercise Metabolism]]|date=Aug 2011|volume=21|issue=4|pages=291–9|pmid=21813912}}</ref> |
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Another recent study found acute AAKG supplementation made no difference in endurance or blood pressure during the course of exercise. In fact, participants that took AAKG prior to exercise had compromised endurance and strength. "Because AAKG supplementation may hinder [[muscular endurance]], the use of these supplements before resistance training should be questioned." <ref>{{cite journal|last=Greer|first=BK|author2=BT Jones|title=Acute arginine supplementation fails to improve muscle endurance or affect blood pressure responses to resistance training|journal=Journal of Strength and Conditioning Research|date=Jul 2011|volume=25|issue=7|pages=1789–94|pmid=21399536|doi=10.1519/JSC.0b013e3181e07569}}</ref> |
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A study has found improvements in 1RM [[bench press]] and [[Wingate test]] from AAKG-use.<ref>{{Cite journal|last=Campbell|first=Bill I.|last2=La Bounty|first2=Paul M.|last3=Roberts|first3=Mike|date=2004-01-01|title=The Ergogenic Potential of Arginine|url=https://dx.doi.org/10.1186/1550-2783-1-2-35|journal=Journal of the International Society of Sports Nutrition|volume=1|pages=35|doi=10.1186/1550-2783-1-2-35|issn=1550-2783|pmc=2129157|pmid=18500948}}</ref> |
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== References == |
== References == |
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Revision as of 19:05, 26 March 2018
Arginine alpha-ketoglutarate (AAKG) is a salt of the amino acid arginine and alpha-ketoglutaric acid. It is marketed as a bodybuilding supplement. The components are intermediates in the metabolism of nitric oxides, but no reputable scientific evidence shows any benefits from taking AAKG as a dietary supplement.