Zeta-pan RNA motif: Difference between revisions
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Zeta-''pan'' RNAs are consistently located upstream of "''pan''" [[operon]]s, which contains [[gene]]s involved in the synthesis of [[pantothenate]], which is a [[vitamin]] that is a precursor of [[coenzyme A]]. This genetic arrangement is consistent with the idea that Zeta-''pan'' RNAs function as [[cis-regulatory element]]s to regulate pantothenate synthesis. |
Zeta-''pan'' RNAs are consistently located upstream of "''pan''" [[operon]]s, which contains [[gene]]s involved in the synthesis of [[pantothenate]], which is a [[vitamin]] that is a precursor of [[coenzyme A]]. This genetic arrangement is consistent with the idea that Zeta-''pan'' RNAs function as [[cis-regulatory element]]s to regulate pantothenate synthesis. |
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Another RNA motif was previously discovered that also is found upstream of ''pan'' operons. This earlier [[pan RNA motif|''pan'' RNA motif]] is, however, not found in Zetaproteobacteria. Both motifs consist of simple [[stem-loop]] [[nucleic acid secondary structure|secondary structures]], although the earlier ''pan'' motif often consists of two stem-loops that are similar to each other. The stem-loops in the earlier ''pan'' motif usually have unpaired [[adenosine]] [[nucleotide]]s in asymmetric locations on both sides of the stem-loop. The Zeta-''pan'' motif has an unpaired adenosine only on its 5' side. Therefore, it is possible that the two motifs are structurally related to each other, but the potential structural relationship between these motifs is not yet (as of 2018) clear. |
Another RNA motif was previously discovered that also is found upstream of ''pan'' operons.<ref name="Weinberg2010">{{cite journal |vauthors=Weinberg Z, Wang JX, Bogue J, etal |title=Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes |journal=Genome Biol |volume=11 |issue=3 |pages=R31 |date=March 2010 |pmid=20230605 |doi=10.1186/gb-2010-11-3-r31 |url= |pmc=2864571}}</ref> This earlier [[pan RNA motif|''pan'' RNA motif]] is, however, not found in Zetaproteobacteria. Both motifs consist of simple [[stem-loop]] [[nucleic acid secondary structure|secondary structures]], although the earlier ''pan'' motif often consists of two stem-loops that are similar to each other. The stem-loops in the earlier ''pan'' motif usually have unpaired [[adenosine]] [[nucleotide]]s in asymmetric locations on both sides of the stem-loop. The Zeta-''pan'' motif has an unpaired adenosine only on its 5' side. Therefore, it is possible that the two motifs are structurally related to each other, but the potential structural relationship between these motifs is not yet (as of 2018) clear. |
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==References== |
==References== |
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Revision as of 08:43, 6 September 2018
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The Zeta-pan RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] Zeta-pan motif RNAs are found in Zetaproteobacteria.
Zeta-pan RNAs are consistently located upstream of "pan" operons, which contains genes involved in the synthesis of pantothenate, which is a vitamin that is a precursor of coenzyme A. This genetic arrangement is consistent with the idea that Zeta-pan RNAs function as cis-regulatory elements to regulate pantothenate synthesis.
Another RNA motif was previously discovered that also is found upstream of pan operons.[2] This earlier pan RNA motif is, however, not found in Zetaproteobacteria. Both motifs consist of simple stem-loop secondary structures, although the earlier pan motif often consists of two stem-loops that are similar to each other. The stem-loops in the earlier pan motif usually have unpaired adenosine nucleotides in asymmetric locations on both sides of the stem-loop. The Zeta-pan motif has an unpaired adenosine only on its 5' side. Therefore, it is possible that the two motifs are structurally related to each other, but the potential structural relationship between these motifs is not yet (as of 2018) clear.
References
- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.
- ^ Weinberg Z, Wang JX, Bogue J, et al. (March 2010). "Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes". Genome Biol. 11 (3): R31. doi:10.1186/gb-2010-11-3-r31. PMC 2864571. PMID 20230605.
{{cite journal}}: CS1 maint: unflagged free DOI (link)