CTAG1B: Difference between revisions

CTAG1B
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1S9W, 2BNQ, 2BNR, 2F53, 2F54, 2P5E, 2P5W, 2PYE, 3GJF, 3HAE, 3KLA
Identifiers
Aliases	CTAG1B, CT6.1, CTAG, CTAG1, ESO1, LAGE-2, LAGE2B, NY-ESO-1, cancer/testis antigen 1B
External IDs	OMIM: 300156; HomoloGene: 133254; GeneCards: CTAG1B; OMA:CTAG1B - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	154,619,282 bp
RNA expression pattern
	Top expressed in
	testicle; ; stromal cell of endometrium; ; skeletal muscle tissue; ; cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; Brodmann area 9; ; prefrontal cortex; ; blood; ; gastrocnemius muscle;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Orthologs
	1485
	n/a
	ENSG00000184033
	n/a
	P78358
	n/a
	NM_001327
	n/a
	NP_640343; NP_001318
	n/a
	Wikidata
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Revision as of 08:22, 6 December 2018

Cancer/testis antigen 1 is a protein that in humans is encoded by the CTAG1B gene.^[3]^[4]^[5] It is most often referenced by its Alias NY-ESO-1

Template:PBB SummaryIt is a tumor antigen, making it a prime target for cancer immunotherpy ^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184033 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen YT, Boyer AD, Viars CS, Tsang S, Old LJ, Arden KC (Jun 1998). "Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome Xq28". Cytogenet Cell Genet. 79 (3–4): 237–40. doi:10.1159/000134734. PMID 9605863.
^ Aradhya S, Bardaro T, Galgoczy P, Yamagata T, Esposito T, Patlan H, Ciccodicola A, Munnich A, Kenwrick S, Platzer M, D'Urso M, Nelson DL (Nov 2001). "Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes". Hum Mol Genet. 10 (22): 2557–67. doi:10.1093/hmg/10.22.2557. PMID 11709543.
^ "Entrez Gene: CTAG1B cancer/testis antigen 1B".
^ Decock, Julie; Bedognetti, Davide; Dermime, Said; Hendrickx, Wouter; Roelands, Jessica; Al-Khadairi, Ghaneya; Thomas, Remy (2018). "NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives". Frontiers in Immunology. 9. doi:10.3389/fimmu.2018.00947. ISSN 1664-3224. PMC 5941317. PMID 29770138.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)

External links

Human CTAG1B genome location and CTAG1B gene details page in the UCSC Genome Browser.

@@ Line 1: / Line 1: @@
 {{Infobox_gene}}
-'''Cancer/testis antigen 1''' is a [[protein]] that in humans is encoded by the ''CTAG1B'' [[gene]].<ref name="pmid9605863">{{cite journal | vauthors = Chen YT, Boyer AD, Viars CS, Tsang S, Old LJ, Arden KC | title = Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome Xq28 | journal = Cytogenet Cell Genet | volume = 79 | issue = 3-4 | pages = 237–40 |date=Jun 1998 | pmid = 9605863 | pmc =  | doi =10.1159/000134734  }}</ref><ref name="pmid11709543">{{cite journal | vauthors = Aradhya S, Bardaro T, Galgoczy P, Yamagata T, Esposito T, Patlan H, Ciccodicola A, Munnich A, Kenwrick S, Platzer M, D'Urso M, Nelson DL | title = Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes | journal = Hum Mol Genet | volume = 10 | issue = 22 | pages = 2557–67 |date=Nov 2001 | pmid = 11709543 | pmc =  | doi =10.1093/hmg/10.22.2557  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CTAG1B cancer/testis antigen 1B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1485| accessdate = }}</ref>
+'''Cancer/testis antigen 1''' is a [[protein]] that in humans is encoded by the ''CTAG1B'' [[gene]].<ref name="pmid9605863">{{cite journal | vauthors = Chen YT, Boyer AD, Viars CS, Tsang S, Old LJ, Arden KC | title = Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome Xq28 | journal = Cytogenet Cell Genet | volume = 79 | issue = 3-4 | pages = 237–40 |date=Jun 1998 | pmid = 9605863 | pmc =  | doi =10.1159/000134734  }}</ref><ref name="pmid11709543">{{cite journal | vauthors = Aradhya S, Bardaro T, Galgoczy P, Yamagata T, Esposito T, Patlan H, Ciccodicola A, Munnich A, Kenwrick S, Platzer M, D'Urso M, Nelson DL | title = Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes | journal = Hum Mol Genet | volume = 10 | issue = 22 | pages = 2557–67 |date=Nov 2001 | pmid = 11709543 | pmc =  | doi =10.1093/hmg/10.22.2557  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CTAG1B cancer/testis antigen 1B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1485| accessdate = }}</ref> It is most often referenced by its Alias [[NY-ESO-1]]
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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 | summary_text =
+}}It is a [[tumor antigen]], making it a prime target for [[Cancer immunotherapy|cancer immunotherpy]] <ref>{{Cite journal|last=Decock|first=Julie|last2=Bedognetti|first2=Davide|last3=Dermime|first3=Said|last4=Hendrickx|first4=Wouter|last5=Roelands|first5=Jessica|last6=Al-Khadairi|first6=Ghaneya|last7=Thomas|first7=Remy|date=2018|title=NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives|url=https://www.frontiersin.org/articles/10.3389/fimmu.2018.00947/full|journal=Frontiers in Immunology|language=English|volume=9|doi=10.3389/fimmu.2018.00947|issn=1664-3224|pmc=PMC5941317|pmid=29770138}}</ref>
-}}It is a [[tumor antigen]].
 ==References==

Revision as of 08:22, 6 December 2018

References

External links

Further reading