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| workplaces = [[Polytechnic University of Milan]]
| workplaces = [[Polytechnic University of Milan]]
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'''Antonio Pedotti''' is an Italian scientist, bioengineer and researcher. He is Emeritus Professor of Biomedical Technologies at the [[Polytechnic University of Milan]] where he has been chair of the Bioengineering Department, member of the Academic Senate and Director of the Biomedical Technologies Laboratory. He is the former director of the Bioengineering Center of Milan cofounded by the Politecnico and the Scientific Medical Institute Don Gnocchi.<ref name=MIL>{{cite web|url=https://www.deib.polimi.it/eng/people/details/59754|title=Antonio Pedotti}}</ref>
'''Antonio Pedotti''' is an Italian scientist, bioengineer and researcher. He is Emeritus Professor of Biomedical Technologies at the [[Polytechnic University of Milan]] where he has been chair of the Bioengineering Department, member of the Academic Senate and Director of the Biomedical Technologies Laboratory. He is the former director of the Bioengineering Center of Milan cofounded by the Politecnico and the Scientific Medical Institute Don Gnocchi.<ref name=MIL>{{Cite web|url=https://www.deib.polimi.it/eng/people/details/59754|title=Dipartimento di Elettronica, Informazione e Bioingegneria|website=www.deib.polimi.it}}</ref>


Pedotti has authored over 300 publications including scientific papers, books and patents regarding the interdisciplinary research on IT, biological systems and medicine. He has worked on simulation of biological system, signal processing, 3D multimodal imaging and multimedia technologies to improve knowledge and to develop techniques and tools that address critical medical needs especially for movement analysis and rehabilitation, cardiovascular monitoring, respiratory function and radiotherapy.<ref>{{cite web|url=https://scholar.google.it/citations?user=msPtOksAAAAJ&hl=it|title=Antonio Pedotti}}</ref>
Pedotti has authored over 300 publications including scientific papers, books and patents regarding the interdisciplinary research on IT, biological systems and medicine. He has worked on simulation of biological system, signal processing, 3D multimodal imaging and multimedia technologies to improve knowledge and to develop techniques and tools that address critical medical needs especially for movement analysis and rehabilitation, cardiovascular monitoring, respiratory function and radiotherapy.<ref>{{Cite web|url=https://scholar.google.it/citations?user=msPtOksAAAAJ&hl=it|title=antonio pedotti|website=scholar.google.it}}</ref>


Pedotti has been Chairman of the European Society of Engineering and Medicine, the International Society of Electrophysiology and Kinesiology,<ref>{{cite web|url=https://isek.org/about-isek/|title=About ISEK}}</ref> President of the Italian Society for Movement Analysis in Clinics and of the Italian Association of the Medical and Biological Engineering.<ref>{{cite web|url=https://link.springer.com/chapter/10.1007%2F978-3-642-30160-5_76|title=Italian Association of Medical and Biological (AIIMB)}}</ref>
Pedotti has been Chairman of the European Society of Engineering and Medicine, the International Society of Electrophysiology and Kinesiology,<ref>{{Cite web|url=https://isek.org/about-isek/|title=About ISEK}}</ref> President of the Italian Society for Movement Analysis in Clinics and of the Italian Association of the Medical and Biological Engineering.<ref>{{Cite book|url=https://doi.org/10.1007/978-3-642-30160-5_76|title=Italian Association of Medical and Biological (AIIMB)|first1=Herbert|last1=Voigt|first2=Ratko|last2=Magjarević|editor-first1=Herbert|editor-last1=Voigt|editor-first2=Ratko|editor-last2=Magjarevic|date=October 26, 2014|publisher=Springer|pages=176–179|via=Springer Link|doi=10.1007/978-3-642-30160-5_76}}</ref>


Pedotti has been an editorial board member of several magazines and an editor of the ''Studies in Health Technology and Informatics'' series.
Pedotti has been an editorial board member of several magazines and an editor of the ''Studies in Health Technology and Informatics'' series.
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Pedotti received his Dr. Eng. degree in electrical engineering from the Politecnico di Milano where from 1970 to 1981 he taught as Associate Professor of Automatic Control, and later as Full Professor of Bioengineering. From 1979 to 1990 he was designated national representative in the COMAC-BME of the [[European Union]].<ref name=MIL/>
Pedotti received his Dr. Eng. degree in electrical engineering from the Politecnico di Milano where from 1970 to 1981 he taught as Associate Professor of Automatic Control, and later as Full Professor of Bioengineering. From 1979 to 1990 he was designated national representative in the COMAC-BME of the [[European Union]].<ref name=MIL/>


In 1984 he was appointed member of the Superior Health Council by the [[Ministry of Health (Italy)|Italian Ministry of Health]] and from 1987 to 1995 scientific director of the scientific health care Institute don Gnocchi Fnd. In 1986 he cofounded Bioengineering Technology and Systems (BTS) Company he served as scientific advisor. In 2000 he contributed to establish the Italian National Center of Oncological Hadrontheraphy (CNAO), a cancer centre specializing in translational research and Hadrontherapy with protons and carbon ions, where he is serving as member of the Board of Governors since the beginning.<ref>{{cite web|url=https://fondazionecnao.it/presidenza-e-direzioni|title=Presidenza E Direzioni}}</ref>
In 1984 he was appointed member of the Superior Health Council by the [[Ministry of Health (Italy)|Italian Ministry of Health]] and from 1987 to 1995 scientific director of the scientific health care Institute don Gnocchi Fnd. In 1986 he cofounded Bioengineering Technology and Systems (BTS) Company he served as scientific advisor. In 2000 he contributed to establish the Italian National Center of Oncological Hadrontheraphy (CNAO), a cancer centre specializing in translational research and Hadrontherapy with protons and carbon ions, where he is serving as member of the Board of Governors since the beginning.<ref>{{Cite web|url=https://fondazionecnao.it/presidenza-e-direzioni|title=Consiglio di indirizzo|website=fondazionecnao.it}}</ref>


==Research==
==Research==
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===Pedotti diagrams and Elite for 3D analysis of movement===
===Pedotti diagrams and Elite for 3D analysis of movement===
Pedotti has worked on new methods and technologies for the analysis of complex movements to investigate neuroscience areas such as neuromotor control, brain plasticity and learning. He has researched on the development of such innovations for applications in neurological disorders, orthopedics, rehabilitation, ergonomics and optimization of motor performances. He developed the Pedotti diagrams of gait and the computer vision Elite for 3D analysis of movement in this context.<ref>{{cite web|url=https://ieeexplore.ieee.org/abstract/document/4121971|title=Elite: A Digital Dedicated Hardware System for Movement Analysis Via Real-Time TV Signal Processing}}</ref> His developments are used in clinical practice and have also been installed in the space platforms MIR and ISS to investigate astronaut motor performances in microgravity.<ref>{{cite web|url=https://www.cambridge.org/core/journals/robotica/article/elite-a-goal-oriented-vision-system-for-moving-objects-detection/9D3FA69CBF99BEC79C5EBC5FD87F3058|title=ELITE: A goal oriented vision system for moving objects detection}}</ref>
Pedotti has worked on new methods and technologies for the analysis of complex movements to investigate neuroscience areas such as neuromotor control, brain plasticity and learning. He has researched on the development of such innovations for applications in neurological disorders, orthopedics, rehabilitation, ergonomics and optimization of motor performances. He developed the Pedotti diagrams of gait and the computer vision Elite for 3D analysis of movement in this context.<ref>{{Cite journal|url=https://ieeexplore.ieee.org/abstract/document/4121971|title=Elite: A Digital Dedicated Hardware System for Movement Analysis Via Real-Time TV Signal Processing|first1=G.|last1=Ferrigno|first2=A.|last2=Pedotti|date=November 26, 1985|journal=IEEE Transactions on Biomedical Engineering|volume=BME-32|issue=11|pages=943–950|via=IEEE Xplore|doi=10.1109/TBME.1985.325627}}</ref> His developments are used in clinical practice and have also been installed in the space platforms MIR and ISS to investigate astronaut motor performances in microgravity.<ref>{{Cite journal|url=https://www.cambridge.org/core/journals/robotica/article/elite-a-goal-oriented-vision-system-for-moving-objects-detection/9D3FA69CBF99BEC79C5EBC5FD87F3058|title=ELITE: A goal oriented vision system for moving objects detection|first1=N. A.|last1=Borghese|first2=M. Di|last2=Rienzo|first3=G.|last3=Ferrigno|first4=A.|last4=Pedotti|date=July 26, 1991|journal=Robotica|volume=9|issue=3|pages=275–282|via=Cambridge University Press|doi=10.1017/S0263574700006433}}</ref>


===Functional rehabilitation and recovery of disabled people===
===Functional rehabilitation and recovery of disabled people===
Pedotti has also worked on creating technical aids and devices for functional rehabilitation and recovery of disabled people<ref>{{cite web|url=https://ieeexplore.ieee.org/abstract/document/5783422|title=Functional Evaluation and Rehabilitation Engineering}}</ref> including neuroprosthesis<ref>{{cite web|url=http://curis.ku.dk/ws/files/19118817/Preliminary_results_of_muscle__1996_.pdf|title=Preliminary results of muscle strength endurance and metabolism in the wrist extensors of tetraplegics following 12 weeks of electrically induced training. In:"Neuroprosthetics. From basic research to clinical applications"}}</ref> and brain-computer interface and the service for information and evaluation of technical aids (SIVA).
Pedotti has also worked on creating technical aids and devices for functional rehabilitation and recovery of disabled people<ref>{{Cite journal|url=https://ieeexplore.ieee.org/abstract/document/5783422|title=Functional Evaluation and Rehabilitation Engineering|first1=A.|last1=Aliverti|first2=C.|last2=Frigo|first3=G.|last3=Andreoni|first4=G.|last4=Baroni|first5=A.|last5=Bonarini|first6=P.|last6=Cerveri|first7=M.|last7=Crivellini|first8=R.|last8=Dellacà|first9=G.|last9=Ferrigno|first10=M.|last10=Galli|first11=A.|last11=Pedrocchi|first12=R.|last12=Rodano|first13=G. C.|last13=Santambrogio|first14=G.|last14=Tognola|first15=A.|last15=Pedotti|date=May 26, 2011|journal=IEEE Pulse|volume=2|issue=3|pages=24–34|via=IEEE Xplore|doi=10.1109/MPUL.2011.941520}}</ref> including neuroprosthesis<ref>{{Cite web|url=http://curis.ku.dk/ws/files/19118817/Preliminary_results_of_muscle__1996_.pdf|title=Preliminary results of muscle strength endurance and metabolism in the wrist extensors of tetraplegics following 12 weeks of electrically induced training. In:"Neuroprosthetics. From basic research to clinical applications"}}</ref> and brain-computer interface and the service for information and evaluation of technical aids (SIVA).


===Cardiovascular research===
===Cardiovascular research===
In the field of cardiovascular research, Pedotti contributed to the development of new algorithms and technologies for continuous monitoring and processing of BP and HR signals in order to investigate the baroreflex control and its role in hypertension.<ref>{{cite web|url=https://journals.physiology.org/doi/full/10.1152/ajpregu.2001.280.3.r744|title=Baroreflex effectiveness index: an additional measure of baroreflex control of heart rate in daily life}}</ref>
In the field of cardiovascular research, Pedotti contributed to the development of new algorithms and technologies for continuous monitoring and processing of BP and HR signals in order to investigate the baroreflex control and its role in hypertension.<ref>{{Cite journal|url=https://journals.physiology.org/doi/full/10.1152/ajpregu.2001.280.3.r744|title=Baroreflex effectiveness index: an additional measure of baroreflex control of heart rate in daily life|first1=Marco|last1=Di Rienzo|first2=Gianfranco|last2=Parati|first3=Paolo|last3=Castiglioni|first4=Roberto|last4=Tordi|first5=Giuseppe|last5=Mancia|first6=Antonio|last6=Pedotti|date=March 1, 2001|journal=American Journal of Physiology-Regulatory, Integrative and Comparative Physiology|volume=280|issue=3|pages=R744–R751|via=journals.physiology.org (Atypon)|doi=10.1152/ajpregu.2001.280.3.R744}}</ref>


=== Cancer Research ===
=== Cancer Research ===
Pedotti has conducted oncological research centering on radiomics, sensors and robotics, to improve methods and technologies for patient positioning and computer aided tumor targeting in radiotherapy and hadrontherapy with protons and carbon ions.<ref>{{cite web|url=https://www.tandfonline.com/doi/abs/10.3109/10929080009148897|title=Real-Time Opto-Electronic Verification of Patient Position in Breast Cancer Radiotherapy}}</ref>
Pedotti has conducted oncological research centering on radiomics, sensors and robotics, to improve methods and technologies for patient positioning and computer aided tumor targeting in radiotherapy and hadrontherapy with protons and carbon ions.<ref>{{Cite journal|url=https://doi.org/10.3109/10929080009148897|title=Real-Time Opto-Electronic Verification of Patient Position in Breast Cancer Radiotherapy|first1=Guido|last1=Baroni|first2=Giancarlo|last2=Ferrigno|first3=Roberto|last3=Orecchia|first4=Antonio|last4=Pedotti|date=January 1, 2000|journal=Computer Aided Surgery|volume=5|issue=4|pages=296–306|via=Taylor and Francis+NEJM|doi=10.3109/10929080009148897|pmid=11029162}}</ref>


=== Optoelectronic Pletismography ===
=== Optoelectronic Pletismography ===
In the context of pneumology and respiratory diseases, Pedotti is one of the inventors of the Optoelectronic Pletismography, which is a method to evaluate ventilation through an external measurement of the chest wall surface motion.<ref>{{cite web|url=https://re.public.polimi.it/handle/11311/762877#.X37iDMgzZdg|title=Measurement of chest wall volume changes by optoelectronic plethysmography (OEP) in newborns during CPAP.}}</ref> He also contributed in the improvement of forced oscillation technique (FOT) for evaluating the respiratory system resistance and reactance during spontaneous ventilation and mechanical ventilation.<ref>{{cite web|url=https://erj.ersjournals.com/content/23/2/232.short|title=Detection of expiratory flow limitation in COPD using the forced oscillation technique}}</ref>
In the context of pneumology and respiratory diseases, Pedotti is one of the inventors of the Optoelectronic Pletismography, which is a method to evaluate ventilation through an external measurement of the chest wall surface motion.<ref>{{Cite web|url=https://re.public.polimi.it/handle/11311/762877#.X37iDMgzZdg|title=Measurement of chest wall volume changes by optoelectronic plethysmography (OEP) in newborns during CPAP.|website=re.public.polimi.it}}</ref> He also contributed in the improvement of forced oscillation technique (FOT) for evaluating the respiratory system resistance and reactance during spontaneous ventilation and mechanical ventilation.<ref>{{Cite journal|url=https://erj.ersjournals.com/content/23/2/232|title=Detection of expiratory flow limitation in COPD using the forced oscillation technique|first1=R. L.|last1=Dellacà|first2=P.|last2=Santus|first3=A.|last3=Aliverti|first4=N.|last4=Stevenson|first5=S.|last5=Centanni|first6=P. T.|last6=Macklem|first7=A.|last7=Pedotti|first8=P. M. A.|last8=Calverley|date=February 1, 2004|journal=European Respiratory Journal|volume=23|issue=2|pages=232–240|via=erj.ersjournals.com|doi=10.1183/09031936.04.00046804|pmid=14979497}}</ref>


== Bibliography ==
== Bibliography ==

Revision as of 06:02, 26 October 2020

Antonio Pedotti
Born
Brenta, Lombardy
NationalityItalian
Occupation(s)Scientist, bioengineer and researcher
Academic work
InstitutionsPolytechnic University of Milan

Antonio Pedotti is an Italian scientist, bioengineer and researcher. He is Emeritus Professor of Biomedical Technologies at the Polytechnic University of Milan where he has been chair of the Bioengineering Department, member of the Academic Senate and Director of the Biomedical Technologies Laboratory. He is the former director of the Bioengineering Center of Milan cofounded by the Politecnico and the Scientific Medical Institute Don Gnocchi.[1]

Pedotti has authored over 300 publications including scientific papers, books and patents regarding the interdisciplinary research on IT, biological systems and medicine. He has worked on simulation of biological system, signal processing, 3D multimodal imaging and multimedia technologies to improve knowledge and to develop techniques and tools that address critical medical needs especially for movement analysis and rehabilitation, cardiovascular monitoring, respiratory function and radiotherapy.[2]

Pedotti has been Chairman of the European Society of Engineering and Medicine, the International Society of Electrophysiology and Kinesiology,[3] President of the Italian Society for Movement Analysis in Clinics and of the Italian Association of the Medical and Biological Engineering.[4]

Pedotti has been an editorial board member of several magazines and an editor of the Studies in Health Technology and Informatics series.

Career

Pedotti received his Dr. Eng. degree in electrical engineering from the Politecnico di Milano where from 1970 to 1981 he taught as Associate Professor of Automatic Control, and later as Full Professor of Bioengineering. From 1979 to 1990 he was designated national representative in the COMAC-BME of the European Union.[1]

In 1984 he was appointed member of the Superior Health Council by the Italian Ministry of Health and from 1987 to 1995 scientific director of the scientific health care Institute don Gnocchi Fnd. In 1986 he cofounded Bioengineering Technology and Systems (BTS) Company he served as scientific advisor. In 2000 he contributed to establish the Italian National Center of Oncological Hadrontheraphy (CNAO), a cancer centre specializing in translational research and Hadrontherapy with protons and carbon ions, where he is serving as member of the Board of Governors since the beginning.[5]

Research

Pedotti's research has been focused on movement science, motor disorders and rehabilitation, cardiovascular and pulmonary diseases and cancer treatment.

Pedotti diagrams and Elite for 3D analysis of movement

Pedotti has worked on new methods and technologies for the analysis of complex movements to investigate neuroscience areas such as neuromotor control, brain plasticity and learning. He has researched on the development of such innovations for applications in neurological disorders, orthopedics, rehabilitation, ergonomics and optimization of motor performances. He developed the Pedotti diagrams of gait and the computer vision Elite for 3D analysis of movement in this context.[6] His developments are used in clinical practice and have also been installed in the space platforms MIR and ISS to investigate astronaut motor performances in microgravity.[7]

Functional rehabilitation and recovery of disabled people

Pedotti has also worked on creating technical aids and devices for functional rehabilitation and recovery of disabled people[8] including neuroprosthesis[9] and brain-computer interface and the service for information and evaluation of technical aids (SIVA).

Cardiovascular research

In the field of cardiovascular research, Pedotti contributed to the development of new algorithms and technologies for continuous monitoring and processing of BP and HR signals in order to investigate the baroreflex control and its role in hypertension.[10]

Cancer Research

Pedotti has conducted oncological research centering on radiomics, sensors and robotics, to improve methods and technologies for patient positioning and computer aided tumor targeting in radiotherapy and hadrontherapy with protons and carbon ions.[11]

Optoelectronic Pletismography

In the context of pneumology and respiratory diseases, Pedotti is one of the inventors of the Optoelectronic Pletismography, which is a method to evaluate ventilation through an external measurement of the chest wall surface motion.[12] He also contributed in the improvement of forced oscillation technique (FOT) for evaluating the respiratory system resistance and reactance during spontaneous ventilation and mechanical ventilation.[13]

Bibliography

Selected books

  • Restoration of Walking for Paraplegics: Recent Advancements and Trends (1992) ISBN: 978-9051990942
  • Electrophysiological Kinesiology (1993) ISBN: 978-9051990959
  • Neuroprosthetics: from Basic Research to Clinical Applications (1996) ISBN: 978-3540610847
  • Methodology and clinical applications of blood pressure and heart rate analysis(1999) ISBN: 978-90-5199-436-0.
  • Mechanics of Breathing: New Insights from New Technologies (2014) ISBN: 978-8847056473

Selected Articles

  • Mancia G., Ferrari A., Gregorini L., Parati G., Pomidossi G., Bertinieri G., Grassi G., Di Rienzo M., Pedotti A., Zanchetti A., "Blood pressure and heart rate variabilities in normotensive and hypertensive human beings", Circ. Res., 53(1): 96-104, July 1983.
  • Ferrigno G., Pedotti A., "ELITE: a digital dedicated hardware system for movement analysis via real-time TV signal processing", IEEE Trans. Biomed. Eng., 32(11): 943-950, November 1985.
  • Pedotti A., Krishnan V.V., Stark L., "Optimization of muscle-force sequencing in human locomotion", Mathematical Biosciences, 38, pp. 57-76, 1978.
  • Baroni G., Ferrigno G., Orecchia R., Pedotti A., “Real-time three-dimensional motion analysis for patient positioning verification”, Radiother. Oncol., 54(1): 21-27, January 2000.
  • Mouchnino L., Aurenty R., Massion J., Pedotti A., "Coordination between equilibrium and head-trunk orientation during leg movement: a new strategy build up by training", J. Neurophysiol., 67(6): 1587-1598, June 1992.
  • Cala S.J., Kenyon C.M., Ferrigno G., Carnevali P., Aliverti A., Pedotti A., Macklem P.T., Rochester D.F., “Chest wall and lung volume estimation by optical reflectance motion analysis”, J. Appl. Physiol., 81(6): 2680-2689, December 1996
  • Ferrarin M., Rizzone M., Bergamasco B., Lanotte M., Recalcati M., Pedotti A., Lopiano L., "Effects of bilateral subthalamic stimulation on gait kinematics and kinetics in Parkinson's disease", Exp. Brain Res., 160(4): 517-527, January 2005
  • Pedotti A., "A study of motor coordination and neuromuscular activities in human locomotion", Biol. Cybern., 26(1): 53-62, March 1977.

References

  1. ^ a b "Dipartimento di Elettronica, Informazione e Bioingegneria". www.deib.polimi.it.
  2. ^ "antonio pedotti". scholar.google.it.
  3. ^ "About ISEK".
  4. ^ Voigt, Herbert; Magjarević, Ratko (October 26, 2014). Voigt, Herbert; Magjarevic, Ratko (eds.). Italian Association of Medical and Biological (AIIMB). Springer. pp. 176–179. doi:10.1007/978-3-642-30160-5_76 – via Springer Link.
  5. ^ "Consiglio di indirizzo". fondazionecnao.it.
  6. ^ Ferrigno, G.; Pedotti, A. (November 26, 1985). "Elite: A Digital Dedicated Hardware System for Movement Analysis Via Real-Time TV Signal Processing". IEEE Transactions on Biomedical Engineering. BME-32 (11): 943–950. doi:10.1109/TBME.1985.325627 – via IEEE Xplore.
  7. ^ Borghese, N. A.; Rienzo, M. Di; Ferrigno, G.; Pedotti, A. (July 26, 1991). "ELITE: A goal oriented vision system for moving objects detection". Robotica. 9 (3): 275–282. doi:10.1017/S0263574700006433 – via Cambridge University Press.
  8. ^ Aliverti, A.; Frigo, C.; Andreoni, G.; Baroni, G.; Bonarini, A.; Cerveri, P.; Crivellini, M.; Dellacà, R.; Ferrigno, G.; Galli, M.; Pedrocchi, A.; Rodano, R.; Santambrogio, G. C.; Tognola, G.; Pedotti, A. (May 26, 2011). "Functional Evaluation and Rehabilitation Engineering". IEEE Pulse. 2 (3): 24–34. doi:10.1109/MPUL.2011.941520 – via IEEE Xplore.
  9. ^ "Preliminary results of muscle strength endurance and metabolism in the wrist extensors of tetraplegics following 12 weeks of electrically induced training. In:"Neuroprosthetics. From basic research to clinical applications"" (PDF).
  10. ^ Di Rienzo, Marco; Parati, Gianfranco; Castiglioni, Paolo; Tordi, Roberto; Mancia, Giuseppe; Pedotti, Antonio (March 1, 2001). "Baroreflex effectiveness index: an additional measure of baroreflex control of heart rate in daily life". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 280 (3): R744–R751. doi:10.1152/ajpregu.2001.280.3.R744 – via journals.physiology.org (Atypon).
  11. ^ Baroni, Guido; Ferrigno, Giancarlo; Orecchia, Roberto; Pedotti, Antonio (January 1, 2000). "Real-Time Opto-Electronic Verification of Patient Position in Breast Cancer Radiotherapy". Computer Aided Surgery. 5 (4): 296–306. doi:10.3109/10929080009148897. PMID 11029162 – via Taylor and Francis+NEJM.
  12. ^ "Measurement of chest wall volume changes by optoelectronic plethysmography (OEP) in newborns during CPAP". re.public.polimi.it.
  13. ^ Dellacà, R. L.; Santus, P.; Aliverti, A.; Stevenson, N.; Centanni, S.; Macklem, P. T.; Pedotti, A.; Calverley, P. M. A. (February 1, 2004). "Detection of expiratory flow limitation in COPD using the forced oscillation technique". European Respiratory Journal. 23 (2): 232–240. doi:10.1183/09031936.04.00046804. PMID 14979497 – via erj.ersjournals.com.
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