EF-24: Difference between revisions
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Revision as of 23:08, 22 December 2020
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| Formula | C19H15F2NO |
| Molar mass | 311.332 g·mol−1 |
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EF-24 is a compound that is a synthetic analogue of curcumin, a bioactive phytochemical from turmeric. Curcumin has antioxidant, anti-inflammatory and anti-cancer properties in vitro but has low potency and very poor bioavailability when taken orally, resulting in limited efficacy. EF-24 was developed to try and improve upon these properties, and has been found to be around 10x more potent than curcumin and with much higher systemic bioavailability. It has never been developed for medical use, though research continues to investigate whether it may be useful as an adjutant treatment for some cancers alongside conventional chemotherapy drugs.[1][2]
References
- ^ Mosley CA, Liotta DC, Snyder JP. Highly active anticancer curcumin analogues. Adv Exp Med Biol. 2007;595:77-103. doi:10.1007/978-0-387-46401-5_2 PMID 17569206
- ^ He Y, Li W, Hu G, Sun H, Kong Q. Bioactivities of EF24, a Novel Curcumin Analog: A Review. Front Oncol. 2018 Dec 11;8:614. doi:10.3389/fonc.2018.00614 PMID 30619754
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