ADPRHL2

ADP-ribosylhydrolase like 2
PDB rendering based on 2foz.
Available structures PDB 2FOZ, 2FP0, 2G4K
Identifiers
Symbols	ADPRHL2; ARH3; FLJ20446
External IDs	OMIM: 610624 MGI: 2140364 HomoloGene: 9863 GeneCards: ADPRHL2 Gene
EC number	3.2.1.143
Gene Ontology Molecular function • poly(ADP-ribose) glycohydrolase activity • hydrolase activity • metal ion binding Cellular component • nucleus • nucleolus • cytoplasm Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54936	100206
Ensembl	ENSG00000116863	ENSMUSG00000042558
UniProt	Q9NX46	n/a
RefSeq (mRNA)	NM_017825	NM_133883.2
RefSeq (protein)	NP_060295	NP_598644.1
Location (UCSC)	Chr 1: 36.55 – 36.56 Mb	Chr 4: 125.99 – 126 Mb
PubMed search	[1]	[2]

Poly(ADP-ribose) glycohydrolase ARH3 is an enzyme that in humans is encoded by the ADPRHL2 gene.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Kernstock S, Koch-Nolte F, Mueller-Dieckmann J et al (2006). "Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of human ARH3, the first eukaryotic protein-ADP-ribosylhydrolase". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (Pt 3): 224–227. doi:10.1107/S1744309106003435. PMC 2197168. PMID 16511307. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2197168. 
• Gregory SG, Barlow KF, McLay KE et al (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–321. doi:10.1038/nature04727. PMID 16710414. 
• Mueller-Dieckmann C, Kernstock S, Lisurek M et al (2006). "The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation". Proc. Natl. Acad. Sci. U.S.A. 103 (41): 15026–15031. doi:10.1073/pnas.0606762103. PMC 1622773. PMID 17015823. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1622773. 
• Ono T, Kasamatsu A, Oka S, Moss J (2006). "The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases". Proc. Natl. Acad. Sci. U.S.A. 103 (45): 16687–16691. doi:10.1073/pnas.0607911103. PMC 1636516. PMID 17075046. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1636516.