ALG10

ALG10
Identifiers
Aliases	ALG10, ALG10A, DIE2, KCR1, alpha-1,2-glucosyltransferase, ALG10 alpha-1,2-glucosyltransferase
External IDs	OMIM: 618355 MGI: 2146159 HomoloGene: 6030 GeneCards: ALG10
Gene location (Human)
Chr.	Chromosome 12 (human)
End	34,029,694 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	90,117,674 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; Achilles tendon; ; islet of Langerhans; ; stromal cell of endometrium; ; secondary oocyte; ; monocyte; ; appendix; ; smooth muscle tissue; ; rectum; ; ganglionic eminence;
	Top expressed in
	hand; ; secondary oocyte; ; superior cervical ganglion; ; atrioventricular valve; ; otolith organ; ; trigeminal ganglion; ; utricle; ; endocardial cushion; ; medial ganglionic eminence; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity; transferase activity; glycosyltransferase activity; dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	protein glycosylation; dolichol-linked oligosaccharide biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	84920
	380959
	ENSG00000139133
	ENSMUSG00000075470
	Q5BKT4
	Q3UGP8
	NM_032834
	NM_001033441
	NP_116223
	NP_001028613
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1,2-glucosyltransferase ALG10-A is an enzyme that in humans is encoded by the ALG10 gene.^[5] It is a member of the Dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase class of enzymes.

Function[edit]

This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139133 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000075470 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ UniProt ID: Q5BKT4. Retrieved 30 November 2019
^ "Entrez Gene: ALG10 alpha-1,2-glucosyltransferase". Retrieved 30 November 2019.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139133 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000075470 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] UniProt ID: Q5BKT4. Retrieved 30 November 2019

[entrez-6] "Entrez Gene: ALG10 alpha-1,2-glucosyltransferase". Retrieved 30 November 2019.

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