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Amnionless is a protein that in humans is encoded by the AMNgene.[5][6]
Function
A complex of amnionless and cubilin forms the cubam receptor.
The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kalantry S, Manning S, Haub O, Tomihara-Newberger C, Lee HG, Fangman J, Disteche CM, Manova K, Lacy E (Mar 2001). "The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain". Nat Genet. 27 (4): 412–6. doi:10.1038/86912. PMID11279523.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Kozyraki R, Gofflot F (2008). "Multiligand endocytosis and congenital defects: roles of cubilin, megalin and amnionless". Curr. Pharm. Des. 13 (29): 3038–46. doi:10.2174/138161207782110507. PMID17979745.
Wang X, Bornslaeger EA, Haub O; et al. (1996). "A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein". Dev. Biol. 177 (1): 274–90. doi:10.1006/dbio.1996.0162. PMID8660894.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Tomihara-Newberger C, Haub O, Lee HG; et al. (1999). "The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives". Dev. Biol. 204 (1): 34–54. doi:10.1006/dbio.1998.9034. PMID9851841.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Dunn NR, Hogan BL (2001). "How does the mouse get its trunk?". Nat. Genet. 27 (4): 351–2. doi:10.1038/86829. PMID11279507.
Fyfe JC, Madsen M, Højrup P; et al. (2004). "The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless". Blood. 103 (5): 1573–9. doi:10.1182/blood-2003-08-2852. PMID14576052.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Tsang HT, Connell JW, Brown SE; et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID16730941.{{cite journal}}: CS1 maint: multiple names: authors list (link)