Colchicum autumnale

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Colchicum autumnale
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Monocots
Order: Liliales
Family: Colchicaceae
Genus: Colchicum
Species: C. autumnale
Binomial name
Colchicum autumnale
L.

Colchicum autumnale, commonly known as autumn crocus, meadow saffron or naked lady, is a flower that resembles the true crocuses, but blooms in autumn. (This is not a reliable distinction, however, since many true crocuses flower in autumn.) The name "naked lady" comes from the fact that the flowers emerge from the ground long after the leaves have died back.

The species is commonly cultivated in temperate areas.

Colchicum autumnale is the only species of its genus native to the United Kingdom, with notable populations under the stewardship of the County Wildlife Trusts.

Pharmaceutical uses[edit]

The bulb-like corms of Colchicum autumnale contain colchicine, a useful drug with a narrow therapeutic index. Colchicine is approved by the US FDA for the treatment of gout and familial Mediterranean fever. Colchicine is also used in plant breeding to produce polyploid strains. A synthetic chemical compound, called ICT2588, which is similar to one from the autumn crocus, is in the early stages of drug development for the treatment of some types of cancer. In experimental testing it was successfully used to treat breast, bowel, lung and prostate cancers in mice when used in combination with the drug doxorubicin.[1][2]

Toxicity[edit]

Colchicum plants have been mistaken by foragers for ramsons, which they vaguely resemble, but are deadly poisonous due to their colchicine content. The symptoms of colchicine poisoning resemble those of arsenic, and no antidote is known.

Danger of extinction[edit]

The Botanic Gardens Conservation International representing botanic gardens in 120 countries has warned that "400 medicinal plants are at risk of extinction, from over-collection and deforestation, threatening the discovery of future cures for disease", including Colchicum autumnale.[3]

Gallery[edit]

References[edit]

  1. ^ Battison, Leila (2011-09-12). "BBC News - British flowers are the source of a new cancer drug". Bbc.co.uk. Retrieved 2011-11-30. 
  2. ^ Atkinson, Jennifer M.; Falconer, Robert A.; Edwards, Dylan R.; Pennington, Caroline J.; Siller, Catherine S.; Shnyder, Steven D.; Bibby, Michael C.; Patterson, Laurence H. et al. (2010). "Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases". Cancer Research 70 (17): 6902–12. doi:10.1158/0008-5472.CAN-10-1440. PMC 2933508. PMID 20663911. 
  3. ^ "Medicinal plants 'facing threat'". BBC News. 2008-01-19. 

Further reading[edit]