Molecular binding
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Molecular binding is an attractive interaction between two molecules which results in a stable association in which the molecules are in close proximity to each other. The result of molecular binding is formation of a molecular complex.
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[edit] Types
Molecular binding can be classified into the following types:[1]
- non-covalent – no chemical bonds are formed between the two interacting molecules hence the association is fully reversible
- reversible covalent – a chemical bond is formed, however the free energy difference separating the non-bonded reactants from bonded product is near equilibrium and the activation barrier is relatively low such that the reverse reaction which cleaves the chemical bond easily occurs
- irreversible covalent – a chemical bond is formed in which the product is thermodynamically much more stable than the reactants such that the reverse reaction does not take place.
[edit] Examples
Molecules that can participate in molecular binding include proteins, nucleic acids, carbohydrates, lipids, and small organic molecules such as drugs. Hence the types of complexes that form as a result of molecular binding include:
Proteins that form stable complexes with other molecules are often referred to as receptors while their binding partners are called ligands.[5]
[edit] See also
[edit] References
- ^ Smith AJ, Zhang X, Leach AG, Houk KN (January 2009). "Beyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteins". J. Med. Chem. 52 (2): 225–33. doi:10.1021/jm800498e. PMC 2646787. PMID 19053779. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2646787.
- ^ Haian Fu (2004). Protein-protein interactions: methods and applications. Totowa, NJ: Humana Press. ISBN 1-58829-120-0.
- ^ Harald Seitz (2007). Analytics of Protein-DNA Interactions (Advances in Biochemical Engineering / Biotechnology). Berlin: Springer. ISBN 3-540-48147-8.
- ^ Gerd Folkers; Hans-Joachim Böhm; Gisbert Schneider; Raimund Mannhold; Hugo Kubinyi (2003). Protein-ligand interactions from molecular recognition to drug design. Weinheim: Wiley-VCH. ISBN 3-527-30521-1.
- ^ Klotz, Irving M. (1997). Ligand-receptor energetics: a guide for the perplexed. Chichester: John Wiley & Sons. ISBN 0-471-17626-5.
