Bruce H. Lipshutz
Bruce H. Lipshutz (born 1951) is an American chemist. He is a professor at the University of California, Santa Barbara.[1]
Biography
Bruce Lipshutz received his undergraduate degree in chemistry from SUNY Binghamton in 1973. He did his graduate work under the supervision of Professor Harry H. Wasserman at Yale and obtained a PhD degree in 1977. He spent two years at Harvard as a post-doctoral researcher in the group of Nobel Laureate E. J. Corey. Soon after, he accepted a position of Assistant Professor at UCSB rising to the ranks of Professor in 1987. He has received the Alfred P. Sloan Foundation Fellowship and the Camille & Henry Dreyfus Teacher-Scholar Award. In 2011 he was awarded Presidential Green Chemistry Award.[2] Bruce is Co-founder of Zymes LLC.[3]
Contributions
Reagents
- 2-(Trimethylsilyl)ethoxymethyl chloride: hydroxyl protecting group, selectively cleaved with fluoride ion under mild conditions.[4]
- Di-(4-chlorobenzyl)azodicarboxylate (DCAD): recyclable and convenient alternative to diethylazodicarboxylate (DEAD) or diisopropyazodicarboxylate (DIAD) in Mitsunobu reaction.[5]
- Ligated copper hydride.[6][7]
- Heterogeneous catalysts: nickel-on-charcoal, copper-on-charcoal, nickel-in-graphite, copper+nickel-on-charcoal.
Methodologies
- Higher order organocuprates (Lipshutz cuprates).
- Chiral and achiral conjugate reductions.
References
- ^ Department of Chemistry and Biochemistry, UCSB: People, Faculty
- ^ Past Award Entries and Recipients | Green Chemistry | US EPA
- ^ Zymes llc
- ^ β-(Trimethylsilyl)ethoxymethyl chloride. A new reagent for the protection of the hydroxyl group [1]
- ^ Simplification of the Mitsunobu Reaction. Di-p-chlorobenzyl Azodicarboxylate: A New Azodicarboxylate [2]
- ^ (BDP)CuH: A "Hot" Stryker's reagent for Use in Achiral Conjugate Reductions [3]
- ^ Asymmetric Hydrosilylation of Aryl Ketones Catalyzed by Copper Hydride Complexed by Nonracemic Biphenyl Bis-phosphine Ligands [4]
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