CHRNA5

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Cholinergic receptor, nicotinic, alpha 5 (neuronal)
Identifiers
Symbols CHRNA5 ; LNCR2
External IDs OMIM118505 MGI87889 HomoloGene55485 IUPHAR: α5 ChEMBL: 2454 GeneCards: CHRNA5 Gene
RNA expression pattern
PBB GE CHRNA5 206533 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1138 110835
Ensembl ENSG00000169684 ENSMUSG00000035594
UniProt P30532 Q2MKA5
RefSeq (mRNA) NM_000745 NM_176844
RefSeq (protein) NP_000736 NP_789814
Location (UCSC) Chr 15:
78.86 – 78.89 Mb
Chr 9:
54.98 – 55.01 Mb
PubMed search [1] [2]

Neuronal acetylcholine receptor subunit alpha-5 is a protein that in humans is encoded by the CHRNA5 gene.[1][2]

Function[edit]

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit|]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". 

See also[edit]

References[edit]

  1. ^ Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics 9 (2): 278–82. doi:10.1016/0888-7543(91)90253-B. PMID 2004777. 
  2. ^ a b "Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.