CHRNA5

Cholinergic receptor, nicotinic, alpha 5
Identifiers
Symbols	CHRNA5;
External IDs	OMIM: 118505 MGI: 87889 HomoloGene: 55485 IUPHAR: α5 GeneCards: CHRNA5 Gene
Gene Ontology Molecular function • receptor activity • nicotinic acetylcholine-activated cation-selective channel activity • nicotinic acetylcholine-activated cation-selective channel activity • extracellular ligand-gated ion channel activity • ligand-gated ion channel activity • acetylcholine receptor activity Cellular component • plasma membrane • plasma membrane • nicotinic acetylcholine-gated receptor-channel complex • integral to membrane • cell junction • dendrite • neuronal cell body • synapse • postsynaptic membrane Biological process • transport • ion transport • signal transduction • synaptic transmission • behavioral response to nicotine Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1138	110835
Ensembl	ENSG00000169684	ENSMUSG00000035594
UniProt	P30532	n/a
RefSeq (mRNA)	NM_000745	NM_176844.4
RefSeq (protein)	NP_000736	NP_789814.2
Location (UCSC)	Chr 15: 78.86 – 78.89 Mb	Chr 9: 54.83 – 54.86 Mb
PubMed search	[1]	[2]

Neuronal acetylcholine receptor subunit alpha-5 is a protein that in humans is encoded by the CHRNA5 gene.

Function

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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Nicotine Activity on Dopaminergic Neurons edit

See also

• Nicotinic acetylcholine receptor

Further reading

• Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol.. Reviews of Physiology, Biochemistry and Pharmacology 147: 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266. 
• Anand R, Lindstrom J (1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988. 
• Chini B, Clementi F, Hukovic N, Sher E (1992). "Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1572–6. doi:10.1073/pnas.89.5.1572. PMC 48494. PMID 1542648. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=48494. 
• Raimondi E, Rubboli F, Moralli D et al (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits". Genomics 12 (4): 849–50. doi:10.1016/0888-7543(92)90324-L. PMID 1572664. 
• Elliott KJ, Ellis SB, Berckhan KJ et al (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617. 
• Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220. 
• Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand) 43 (3): 433–42. PMID 9193799. 
• Gerzanich V, Wang F, Kuryatov A, Lindstrom J (1998). "alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors". J. Pharmacol. Exp. Ther. 286 (1): 311–20. PMID 9655874. 
• Lentz TL (2000). "Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits". Biochem. Biophys. Res. Commun. 268 (2): 480–4. doi:10.1006/bbrc.2000.2155. PMID 10679230. 
• Groot-Kormelink PJ, Boorman JP, Sivilotti LG (2001). "Formation of functional α3β4α5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach". Br. J. Pharmacol. 134 (4): 789–96. doi:10.1038/sj.bjp.0704313. PMC 1573006. PMID 11606319. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1573006. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Soldà G, Boi S, Duga S et al (2005). "In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs". Gene 345 (2): 155–64. doi:10.1016/j.gene.2004.12.005. PMID 15716100. 

External links

• MeSH CHRNA5+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.