Combretastatin B-1
| |
| Names | |
|---|---|
| Preferred IUPAC name
3-Methoxy-6-[2-(3,4,5-trimethoxyphenyl)ethyl]benzene-1,2-diol | |
| Other names
Combretastatin B1
| |
| Identifiers | |
3D model (JSmol)
|
|
| ChemSpider | |
PubChem CID
|
|
| UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
| Properties | |
| C18H22O6 | |
| Molar mass | 334.36 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Combretastatin B-1 is a combretastatin and a dihydrostilbenoid. It can be found in Combretum caffrum, the Eastern Cape South African bushwillow tree[1] or in Combretum kraussii, the forest bushwillow.[2]
It can be produced by selective hydrogenation of Combretastatin A-1.[1]
It is a potent inhibitor of microtubule assembly in vitro.[1]
References
- ^ a b c Pettit, G. R.; Singh, S. B.; Niven, M. L.; Hamel, E.; Schmidt, J. M. (1987). "Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum". Journal of Natural Products. 50 (1): 119–131. doi:10.1021/np50049a016. PMID 3598594.
- ^ Uteroactive constituents from Combretum kraussii. Bridget K Brookes, Olga V Doudoukina, Lynn C Katsoulis and Joy H D Veale, South African Journal of Chemistry, Dec 99, Vol. 52, Issue 4, page 127 (abstract)
 | This article about an aromatic compound is a stub. You can help Wikipedia by expanding it. |