CytoViva
 |
 | |
| Company type | Corporation |
|---|---|
| Industry | Nanotechnology |
| Headquarters | Auburn, AL , USA |
Area served | International |
Key people | CEO: Samuel M. Lawrence COO: John O. Lawrence VP, Sales & Marketing: Byron J. Cheatham Technology Development Director: James M. Beach Ph.D |
| Website | www.CytoViva.com |
CytoViva, Inc. is a scientific imaging and instrumentation company that develops and markets optical microscopy and hyperspectral imaging technology for nanomaterials, pathogen and general biology applications.[1]
History
The company’s core optical technology was invented by Vitaly Vodyanoy,[2] Physiology Professor and Director of the Biosensor Laboratory at Auburn University. CytoViva commercialized this technology in 2005 and patents for the illumination optics were issued in 2009 (US patents No. 7,542,203,[3] 7,564,623[4]). In 2008, the company introduced hyperspectral imaging technology as an integrated solution with its patented optical microscopy capability.
The company is currently headquartered in Auburn, Alabama at the Auburn Research Park and has distribution partners worldwide. As of 2016, over 300 research laboratories worldwide utilize CytoViva technology.
Products
CytoViva combines patented enhanced darkfield optical microscopy technology with a proprietary hyperspectral imaging capability.[5] This combination of technologies enables optical observation and spectral characterization of a wide range of nanoscale samples, including nanoparticles, pathogens and subcellular materials.[6]
Products include:
- The patented enhanced darkfield illumination system, which replaces the standard microscope condenser, provides up to 10x improved signal-to-noise optical images of nanoscale samples over standard darkfield microscopy. The system incorporates oblique angle, pre-aligned Kohler illumination.[4] The resulting high signal-to-noise image enables direct observation of nanoscale sample elements.
- The dual mode fluorescence module is a transmitted light fluorescent technique that enables real time observation of both fluorescent and non-fluorescent sample elements. This is accomplished through the proportionate mixing of fluorescence excitation light and full spectrum light.[3]
- The hyperspectral microscope system integrates hyperspectral imaging (HSI) onto the microscope to capture spectral image files. These spectral image files can be used to spectrally characterize sample elements such as nanoparticles, pathogens or subcellular materials. Image analysis software enables mapping sample elements based upon their unique spectral fingerprint.[7] In its most general form, hyperspectral microscopy can be used to determine the location of nanoscale materials within a sample. Analysis methods include identifying and mapping materials in composites, conducting mean spectral analysis, and comparisons of comparable materials.[8]
Applications
- Identifying and mapping Ag, Au and other nanoparticles, in cells, tissue or other composite matrix[9]
- Characterizing drug loads and other functional groups added to nanoparticles[10]
- Confirming the presence of carbon nanotubes in tissue and cells[11]
- Detecting airborne carbon nanotubes and other airborne nanomaterials[11]
- Identifying liposomes used as drug delivery vectors[12]
- Mapping quantum dots and fluorescently tagged particles and subcellular structure[13]
- Bacteria, virus and other pathogen detection[14]
- Plant pathology
- Subcellular structure characterization[15]
- Live cell imaging[16]
References
- ^ "New Microscope Technology Offers Real-Time Nano View on Nashville Medical News". nashville.medicalnewsinc.com. Archived from the original on 28 January 2013. Retrieved 22 May 2022.
- ^ "Auburn University College of Veterinary Medicine". Archived from the original on 2012-07-24. Retrieved 2012-09-10.
- ^ a b http://www.patentgenius.com/patent/7542203.html
- ^ a b http://www.patentgenius.com/patent/7564623.html
- ^ "CytoViva, Inc. | InterNano".
- ^ http://www.nanotxstate.org/presentation/NAC_22_Mar_2010.pdf [bare URL PDF]
- ^ "StackPath".
- ^ Raju Badireddy, Appala (2012). "Detection, Characterization, and Abundance of Engineered Nanoparticles in Complex Waters by Hyperspectral Imagery with Enhanced Darkfield Microscopy". Environmental Science & Technology. 46 (18): 10081–10088. Bibcode:2012EnST...4610081B. doi:10.1021/es204140s. PMID 22906208.
- ^ Gastrin Releasing Protein Receptor –Specific Gold Nanorods: Breast and Prostate Tumor-avid Nanovectors for Molecular Imaging Chanda Nripen, Ravi Shukla, Kattesh V. Katti, and Raghuraman Kannan
- ^ Cellular Uptake and Fate of PEGylated Gold Nanoparticles Is Dependent on Both Cell-Penetration Peptides and Particle Size. Eunkeu Oh, James B. Delehanty, Kim E. Sapsford, Kimihiro Susumu, Ramasis Goswami, Juan B. Blanco-Canosa, Philip E. Dawson, Jessica Granek, Megan Shoff, Qin Zhang, Peter L. Goering, Alan Huston, and Igor L. Medintz
- ^ a b Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies. Liying Wang, Vincent Castranova, Anurag Mishra, Bean Chen, Robert R Mercer, Diane Schwegler-Berry, Yon Rojanasakul
- ^ Theranostic liposomes loaded with quantum dots and apomorphine for brain targeting and bioimaging. Chih-Jen Wen, Li-Wen Zhang, Saleh A Al-Suwayeh,3 Tzu-Chen Yen, and Jia-You Fang
- ^ Novel Quantum Dots for Enhanced Tumor Imaging Nanotechnology, 2008. Nair, A., TX Jinhui Shen ; Thevenot, P. ; Tong Cai ; Zhibing Hu ; Liping Tang
- ^ Multimodal Plasmonic Nanosensor for the Detection of Pathogenic Bacteria. Li-Lin Tay, John Hulse, Shannon Ryan, Jamshid Tanha, Jeff Fraser, and Xiaohua WuaB
- ^ Subcellular Fate of Nanodelivery Systems. Volkmar Weissig, Gerard G. M. D'Souza, Dusica Maysinger, Sebastien Boridy, Eliza Hutter
- ^ http://microscopyeducation.com/images/AR_AL_Nov_2004_-_Aetos.pdf [permanent dead link]