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DDE may refer to:
- Delay differential equation
- Dynamic Data Exchange, a Microsoft Windows inter-application data communication protocol
- Dichlorodiphenyldichloroethylene, a chemical that results from the breakdown of DDT
- D.D.E., a Norwegian rock band
- Deep-dose equivalent, a measure of radiation absorbed by the body
- Doctrine of double effect, ethical criteria to evaluate the permissibility of acting when one's otherwise legitimate act may also cause an effect one would normally be obliged to avoid
- Dwight D. Eisenhower, the 34th President of the United States
- Escort destroyer, a US Navy classification for destroyers used between 1945 and 1962
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