File:Warburgh Effect.gif
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Summary
| Description |
English: Myc and HIF-1 regulate glucose metabolism and stimulate the Warburg effect. Myc and HIF-1 are depicted to regulate (dotted lines) genes involved in glucose metabolism (glucose transporter Glut1, HK2, PKM2, LDHA, and PDK1), favoring the conversion of glucose to lactate (glycolysis). Myc is also depicted to stimulate glutamine metabolism through the regulation of glutaminase (GLS). Glutamine is shown converted to α- ketoglutarate (α-KG) for catabolism through the TCA cycle to malate, which is transported into the cytoplasm and converted to pyruvate and then to lactate (glutaminolysis). |
| Date | 24 April 2014 (original upload date) |
| Source | Therapeutic Targeting of Cancer Cell Metabolism: Role of Metabolic Enzymes, Oncogenes and Tumor Suppressor Genes. J Cancer Sci Ther 4: 281-291. |
| Author | Majeed R, Hamid A, Qurishi Y, Qazi AK, Hussain A, et al. (2012) |
| Permission (Reusing this file) |
http://omicsonline.org/1948-5956/JCST-04-281.php?aid=8000 |
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Original upload log
The original description page was here. All following user names refer to en.wikipedia.
| Date/Time | Dimensions | User | Comment |
|---|---|---|---|
| 2014-04-24 06:06 | 604×460× (105201 bytes) | Aayushraman | Uploading a file from a free published source using [[Wikipedia:File_Upload_Wizard|File Upload Wizard]] |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 15:23, 12 November 2014 | | 604 × 460 (103 KB) | Arthunter | Transferred from en.wikipedia |
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