From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Protein NipSnap homolog 2 is a protein that in humans is encoded by the GBAS gene .[ 5] [ 6] [ 7]
Chromosomal region 7p12, which contains GBAS, is amplified in approximately 40% of glioblastomas , the most common and malignant form of central nervous system tumor . The predicted 286-amino acid protein contains a signal peptide , a transmembrane domain , and 2 tyrosine phosphorylation sites. The GBAS transcript is expressed most abundantly in heart and skeletal muscle . GBAS protein might be involved in vesicular transport.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000146729 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029432 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Wang XY, Smith DI, Liu W, James CD (Aug 1998). "GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR". Genomics . 49 (3): 448–51. doi :10.1006/geno.1998.5239 . PMID 9615231 .
^ Seroussi E, Pan HQ, Kedra D, Roe BA, Dumanski JP (Jul 1998). "Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family". Gene . 212 (1): 13–20. doi :10.1016/S0378-1119(98)00098-5 . PMID 9661659 .
^ a b "Entrez Gene: GBAS glioblastoma amplified sequence" .
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