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GTPBP4

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GTPBP4
Identifiers
AliasesGTPBP4, CRFG, NGB, NOG1, GTP binding protein 4
External IDsMGI: 1916487; HomoloGene: 7100; GeneCards: GTPBP4; OMA:GTPBP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012341

NM_027000

RefSeq (protein)

NP_036473

NP_081276

Location (UCSC)Chr 10: 0.99 – 1.02 MbChr 13: 9.02 – 9.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleolar GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP4 gene.[5][6]

GTPases function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G protein-coupled receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107937Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021149Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Laping NJ, Olson BA, Zhu Y (Apr 2001). "Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease". J Am Soc Nephrol. 12 (5): 883–90. doi:10.1681/ASN.V125883. PMID 11316846.
  6. ^ a b "Entrez Gene: GTPBP4 GTP binding protein 4".

Further reading

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