Guggulsterone

Guggulsterone

E-Guggulsterone
Z-Guggulsterone
Names
IUPAC name (8R,9S,10R,13S,14S)-17-Ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
Other names Pregna-4,17-diene-3,16-dione
Identifiers
CAS Number	95975-55-6 (E/Z) Y 39025-24-6 (E) Y 39025-23-5 (Z) Y
3D model (JSmol)	(E): Interactive image (Z): Interactive image
ChEMBL	ChEMBL410683 N
ECHA InfoCard	100.118.937
PubChem CID	6439929 (E) 6450278 (Z)
CompTox Dashboard (EPA)	DTXSID6033538
SMILES (E): O=C1C[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]2(C)/C1=C\C)=O (Z): O=C1C[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]2(C)/C1=C/C)=O
Properties
Chemical formula	C21H28O2
Molar mass	312.453 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Guggulsterone is a plant steroid found in the resin of the guggul plant, Commiphora mukul. Guggulsterone can exist as either of two stereoisomers, E-guggulsterone and Z-guggulsterone. In humans, it acts as an antagonist of the farnesoid X receptor, which was once believed to result in decreased cholesterol synthesis in the liver. Several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone, and levels of low-density lipoprotein ("bad cholesterol") increased in many people. Nevertheless, guggulsterone is an ingredient in many nutritional supplements.