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Hemicentin 1
Symbols HMCN1 ; ARMD1; FBLN6; FIBL-6; FIBL6
External IDs OMIM608548 HomoloGene23741 GeneCards: HMCN1 Gene
Species Human Mouse
Entrez 83872 545370
Ensembl ENSG00000143341 ENSMUSG00000066842
UniProt Q96RW7 n/a
RefSeq (mRNA) NM_031935 NM_001024720
RefSeq (protein) NP_114141 NP_001019891
Location (UCSC) Chr 1:
185.7 – 186.16 Mb
Chr 1:
150.56 – 150.99 Mb
PubMed search [1] [2]

Hemicentin-1 is a protein that in humans is encoded by the HMCN1 gene.[1][2]

This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration.[2]


  1. ^ Vogel BE, Hedgecock EM (Mar 2001). "Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions". Development 128 (6): 883–94. PMID 11222143. 
  2. ^ a b "Entrez Gene: HMCN1 hemicentin 1". 

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