Julie Law
Julie Law | |
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Alma mater | Oregon State University (B.S.)
Johns Hopkins School of Medicine (Ph.D.) University of California, Los Angeles (Postdoctoral fellow) |
Known for | Discovery of protein family that controls DNA methylation |
Awards | Ruth L. Kirschstein National Research Service Award, Rita Allen Scholar, Newsweek magazine “Women of the Future” nominee |
Scientific career | |
Fields | Plant Molecular and Cellular Biology, Epigenetics, Chromatin Based Processes |
Institutions | Salk Institute for Biological Studies |
Doctoral advisor | Dr. Barbara Sollner-Webb |
Julie Law (born c. ) is an American molecular and cellular biologist.[1] Law's pioneering work on DNA methylation patterns led to the discovery of the role of the CLASSY protein family in DNA methylation.[2] Law is currently an associate professor at the Salk Institute for Biological Studies.[3]
Early life and education
Law began her scientific career at the Oregon State University where she completed a B.S. in biochemistry and biophysics.[4] She completed her undergraduate research in the laboratory of Dr. Walt Ream.[4] studying plant-microbe interactions[5] She moved to the east coast to complete her doctoral work in biochemistry at Johns Hopkins School of Medicine under the mentorship of Dr. Barbara Sollner-Webb[4] Law's Ph.D. work uncovered the unique RNA editing mechanisms used by pathogenic eukaryotes called trypanosomes.[6] Following her doctoral work, Law moved back to the west coast to pursue postdoctoral training at the University of California, Los Angeles in the lab of Dr. Steven Jacobsen,[4] where she studied DNA methylation in Arabidopsis, a common model organism in biology allowing her to study epigenetic regulation.[7]
Career and research
Law's postdoctoral work, studying DNA methylation at UC Los Angeles, was followed by her recruitment for a faculty position at the Salk Institute for Biological Studies in 2012.[4] Currently, Law's lab at the Salk Institute studies epigenetic modifications in Arabidopsis thaliana to probe how epigenetic tags are recognized by proteins to regulate gene expression.[8] Law is currently working with several other Salk scientists as a part of the Harnessing Plants Initiative to engineer plants to store more carbon dioxide as a means to harness more carbon dioxide from the atmosphere to combat climate change.[9]
Publications
Selected publications:[10]
- Wu, S., Turner, K.M., Nguyen, N., Raviram, R., Erb, M., Santini, J., Luebeck, J., Rajkumar, U., Diao, Y., Li, B., Zhang, W., Jameson, N., Corces, M.R., Granja, J.M., Chen, X., Coruh, C., Abnousi, A., Houston, J., Ye, Z., Hu, R., Yu, M., Kim, H., Law, J.A., Verhaak, R.G.W., Hu, M., Furnari, F.B., Chang, H.Y., Ren, B., Bafna, V., Mischel, P.S. Circular ecDNA promotes accessible chromatin and high oncogene expression. (2019) Nature. 575(7784):699-703. DOI: 10.1038/s41586-019-1763-5
- Argueso, C.T., Assmann, S.M., Birnbaum, K.D., Chen, S., Dinneny, J.R., Doherty, C.J., Eveland, A.L., Friesner, J., Greenlee, V.R., Law, J.A., Marshall-Colón, A., Mason, G.A., O'Lexy, R., Peck, S.C., Schmitz, R.J., Song, L., Stern, D., Varagona, M.J., Walley, J.W., Williams, C.M. Directions for research and training in plant omics: Big Questions and Big Data. (2019) Plant Direct. 3(4):e00133. DOI: 10.1002/pld3.133
- Bourbousse, C., Vegesna, N., Law, J.A. SOG1 activator and MYB3R repressors regulate a complex DNA damage network in . (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1810582115
- Zhou, M., Palanca, A.M.S., Law, J.A. Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family. (2018) Nature Genetics. 50(6). DOI: 10.1038/s41588-018-0115-y
- Li, D., Palanca, A.M.S., Won, S.Y., Gao, L., Feng, Y., Vashisht, A.A., Liu, L., Zhao, Y., Liu, X., Wu, X., Li, S., Le, B., Kim, Y.J., Yang, G., Li, S., Liu, J., Wohlschlegel, J.A., Guo, H., Mo, B., Chen, X., Law, J.A. The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. (2017) Elife. 6. DOI: 10.7554/eLife.19893
- Zhou, M., Law, J.A. RNA Pol IV and V in gene silencing: Rebel polymerases evolving away from Pol II's rules. (2015) Current Opinion in Plant Biology. 27:154-64. DOI: 10.1016/j.pbi.2015.07.005
- Law, J.A., Du, J., Hale, C.J., Feng, S., Krajewski, K., Palanca, A.M., Strahl, B.D., Patel, D.J., Jacobsen, S.E. Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. (2013) Nature. 498(7454):385-9. DOI: 10.1038/nature12178
- Zhong, X., Hale, C.J., Law, J.A., Johnson, L.M., Feng, S., Tu, A., Jacobsen, S.E. DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons. (2012) Nature Structural & Molecular Biology. 19(9):870-5. DOI: 10.1038/nsmb.2354
- Law, J.A., Vashisht, A.A., Wohlschlegel, J.A., Jacobsen, S.E. SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV. (2011) PLOS Genetics. 7(7):e1002195. DOI: 10.1371/journal.pgen.1002195
- Greenberg, M.V., Ausin, I., Chan, S.W., Cokus, S.J., Cuperus, J.T., Feng, S., Law, J.A., Chu, C., Pellegrini, M., Carrington, J.C., Jacobsen, S.E. Identification of genes required for de novo DNA methylation in Arabidopsis. (2011) Epigenetics. 6(3):344-54.
- Rajakumara, E., Law, J.A., Simanshu, D.K., Voigt, P., Johnson, L.M., Reinberg, D., Patel, D.J., Jacobsen, S.E. A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. (2011) Genes & Development. 25(2):137-52. DOI: 10.1101/gad.1980311
- Guo, L., Yu, Y., Law, J.A., Zhang, X. SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(43):18557-62. DOI: 10.1073/pnas.1010478107
- Law, J.A., Ausin, I., Johnson, L.M., Vashisht, A.A., Zhu, J.K., Wohlschlegel, J.A., Jacobsen, S.E. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. (2010) Current Biology. 20(10):951-6. DOI: 10.1016/j.cub.2010.03.062
- Law, J.A., Jacobsen, S.E. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. (2010) Nature Reviews. Genetics. 11(3):204-20. DOI: 10.1038/nrg2719
- Law, J.A., Jacobsen, S.E. Molecular biology. Dynamic DNA methylation. (2009) Science. 323(5921):1568-9. DOI: 10.1126/science.1172782
- Johnson, L.M., Law, J.A., Khattar, A., Henderson, I.R., Jacobsen, S.E. SRA-domain proteins required for DRM2-mediated de novo DNA methylation. (2008) PLOS Genetics. 4(11):e1000280. DOI: 10.1371/journal.pgen.1000280
Awards
Law has received the following awards:[11]
- 2015 Rita Allen Scholar Award
- 2007 Ruth L. Kirschstein National Research Service Award, National Institutes of Health
- 2000 Howard Hughes Medical Institute Summer Fellowship, Oregon State University
References
- ^ "Salk promotes Nicola Allen and Julie Law to associate professor". Salk Institute for Biological Studies. Retrieved 2019-08-16.
- ^ "Understanding how DNA is selectively tagged with "do not use" marks". Salk Institute for Biological Studies. Retrieved 2019-08-16.
- ^ "Julie Law". Salk Institute for Biological Studies. Retrieved 2019-08-16.
- ^ a b c d e "Julie Law - Rita Allen Foundation". August 1, 2016. Retrieved 2019-08-17.
- ^ "Dr. Walt Ream | Department of Microbiology | Oregon State University". microbiology.science.oregonstate.edu. Retrieved 2019-08-17.
- ^ Sollner-Webb, Barbara; O'Hearn, Sean F.; Huang, Catherine E.; Law, Julie A. (2005-04-01). "In Trypanosoma brucei RNA Editing, Band II Enables Recognition Specifically at Each Step of the U Insertion Cycle". Molecular and Cellular Biology. 25 (7): 2785–2794. doi:10.1128/MCB.25.7.2785-2794.2005. ISSN 0270-7306. PMC 1061641. PMID 15767682.
- ^ Jacobsen, Steven E.; Law, Julie A. (2009-03-20). "Dynamic DNA Methylation". Science. 323 (5921): 1568–1569. doi:10.1126/science.1172782. ISSN 0036-8075. PMID 19299607. S2CID 46619297.
- ^ "Julie Law". Salk Institute for Biological Studies. Retrieved 2020-03-14.
- ^ Sauer, Mark; Burke, Megan. "Salk Scientists Plan To Combat Climate Change With Plants". KPBS Public Media. Retrieved 2020-03-14.
- ^ "Publications". Salk Institute for Biological Studies. Retrieved 2020-03-14.
- ^ "Julie Law". Salk Institute for Biological Studies. Retrieved 2019-08-17.