KPNA6

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Karyopherin alpha 6 (importin alpha 7)
Identifiers
Symbols KPNA6 ; IPOA7; KPNA7
External IDs OMIM610563 MGI1100836 HomoloGene22472 GeneCards: KPNA6 Gene
RNA expression pattern
PBB GE KPNA6 212102 s at tn.png
PBB GE KPNA6 212101 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23633 16650
Ensembl ENSG00000025800 ENSMUSG00000003731
UniProt O60684 O35345
RefSeq (mRNA) NM_012316 NM_008468
RefSeq (protein) NP_036448 NP_032494
Location (UCSC) Chr 1:
32.57 – 32.64 Mb
Chr 4:
129.64 – 129.67 Mb
PubMed search [1] [2]

Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene.[1]

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.[2]

References[edit]

  1. ^ Kohler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, Gorlich D, Hartmann E (Nov 1999). "Evidence for Distinct Substrate Specificities of Importin α Family Members in Nuclear Protein Import". Mol Cell Biol 19 (11): 7782–91. PMC 84838. PMID 10523667. 
  2. ^ "Entrez Gene: KPNA6 karyopherin alpha 6 (importin alpha 7)". 

Further reading[edit]