LARP4

LARP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQK, 3PKN
Identifiers
Aliases	LARP4, PP13296, La ribonucleoprotein domain family member 4
External IDs	MGI: 2443114; HomoloGene: 19173; GeneCards: LARP4; OMA:LARP4 - orthologs
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,914,239 bp
RNA expression pattern
	n/a
	Top expressed in
	tail of embryo; ; genital tubercle; ; morula; ; superior cervical ganglion; ; zygote; ; seminal vesicula; ; hand; ; secondary oocyte; ; parotid gland; ; lacrimal gland;
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; poly(A) binding; RNA binding;
Cellular component	membrane; polysome; cytoplasmic stress granule; cytosolic small ribosomal subunit; cytoplasm; cytosol;
Biological process	regulation of cell morphogenesis; cytoskeleton organization; positive regulation of translation; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	113251
	207214
	ENSG00000161813
	ENSMUSG00000023025
	Q71RC2
	Q8BWW4
NM_001170803; NM_001170804; NM_001170808; NM_052879; NM_199188;
	NM_199190; NM_001330415
	NM_001024526; NM_001080948; NM_001284521; NM_001284522; NM_001284523
NP_001164274; NP_001164275; NP_001164279; NP_001317344; NP_443111;
	NP_954658; NP_954660; NP_001339233; NP_001339234; NP_001339235; NP_001339236; NP_001339237; NP_001339238; NP_001339239; NP_001339240; NP_001339241; NP_001339242; NP_001339243; NP_001339244; NP_001339245; NP_001339246; NP_001339247; NP_001339248; NP_001339249; NP_001339250; NP_001339251; NP_001339252; NP_001339253; NP_001339254; NP_001339255
	NP_001019697; NP_001074417; NP_001271450; NP_001271451; NP_001271452
	Wikidata
View/Edit Human	View/Edit Mouse

La-related protein 4 is a protein that in humans is encoded by the LARP4 gene.^[4]^[5] LARP4 is an RNA-binding protein which consists of a La motif (LaM), RNA recognition motif (RRM) and a putative PABP binding motif. It has been shown that LARP4 is involved in mRNA stability.^[6]

LARP4 is known to regulate cancer cell migration and invasion by altering cell shape.^[7] It is also reported to be a glioma tumor suppressor.^[8]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023025 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: LARP4 La ribonucleoprotein domain family, member 4".
^ Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ (February 2011). "La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability". Molecular and Cellular Biology. 31 (3): 542–56. doi:10.1128/MCB.01162-10. PMC 3028612. PMID 21098120.
^ Seetharaman S, Flemyng E, Shen J, Conte MR, Ridley AJ (November 2016). "The RNA-binding protein LARP4 regulates cancer cell migration and invasion". Cytoskeleton. 73 (11): 680–690. doi:10.1002/cm.21336. PMC 5111583. PMID 27615744.
^ Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S (April 2016). "Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma". Cancer Research. 76 (8): 2254–64. doi:10.1158/0008-5472.CAN-15-2308. PMID 26933087.

Stavraka C, Blagden S (October 2015). "The La-Related Proteins, a Family with Connections to Cancer". Biomolecules. 5 (4): 2701–22. doi:10.3390/biom5042701. PMC 4693254. PMID 26501340.
Kralovics R, Skoda RC (January 2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders". Blood Reviews. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213.
Puigdecanet E, Espinet B, Villa O, Florensa L, Besses C, Serrano S, Solé F (May 2006). "Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemia". Cancer Genetics and Cytogenetics. 167 (1): 39–42. doi:10.1016/j.cancergencyto.2005.08.016. PMID 16682284.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (November 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000023025 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-4] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-5] "Entrez Gene: LARP4 La ribonucleoprotein domain family, member 4".

[6] Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ (February 2011). "La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability". Molecular and Cellular Biology. 31 (3): 542–56. doi:10.1128/MCB.01162-10. PMC 3028612. PMID 21098120.

[7] Seetharaman S, Flemyng E, Shen J, Conte MR, Ridley AJ (November 2016). "The RNA-binding protein LARP4 regulates cancer cell migration and invasion". Cytoskeleton. 73 (11): 680–690. doi:10.1002/cm.21336. PMC 5111583. PMID 27615744.

[8] Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S (April 2016). "Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma". Cancer Research. 76 (8): 2254–64. doi:10.1158/0008-5472.CAN-15-2308. PMID 26933087.

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References

Further reading