LGALS3

Lectin, galactoside-binding, soluble, 3
	; PDB rendering based on 1a3k.
Available structures
PDB	1A3K, 1KJL, 1KJR, 2NMN, 2NMO, 2NN8, 2XG3
Identifiers
Symbols	LGALS3; CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2
External IDs	OMIM: 153619 MGI: 96778 HomoloGene: 37608 GeneCards: LGALS3 Gene
Gene Ontology
Molecular function	• protein binding; • sugar binding; • IgE binding;
Cellular component	• extracellular region; • proteinaceous extracellular matrix; • nucleus; • spliceosomal complex; • cytoplasm; • mitochondrial inner membrane; • plasma membrane; • extracellular matrix;
Biological process	• skeletal system development; • mRNA processing; • RNA splicing; • cell differentiation; • extracellular matrix organization; • innate immune response;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Galectin-3 is a protein that in humans is encoded by the LGALS3 gene.^[1]^[2]^[3] In melanocytic cells LGALS3 gene expression may be regulated by MITF^[4].

[edit] Interactions

LGALS3 has been shown to interact with LGALS3BP.^[5]^[6]^[7]

[edit] See also

Galectin

[edit] References

^ Raz A, Carmi P, Raz T, Hogan V, Mohamed A, Wolman SR (May 1991). "Molecular cloning and chromosomal mapping of a human galactoside-binding protein". Cancer Res 51 (8): 2173–8. PMID 2009535.
^ Barondes SH, Cooper DN, Gitt MA, Leffler H (Sep 1994). "Galectins. Structure and function of a large family of animal lectins". J Biol Chem 269 (33): 20807–10. PMID 8063692.
^ "Entrez Gene: LGALS3 lectin, galactoside-binding, soluble, 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3958.
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
^ Rosenberg, I; Cherayil B J, Isselbacher K J, Pillai S (Oct. 1991). "Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin". J. Biol. Chem. (UNITED STATES) 266 (28): 18731–6. ISSN 0021-9258. PMID 1917996.
^ Koths, K; Taylor E, Halenbeck R, Casipit C, Wang A (Jul. 1993). "Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain". J. Biol. Chem. (UNITED STATES) 268 (19): 14245–9. ISSN 0021-9258. PMID 8390986.
^ Tinari, N; Kuwabara I, Huflejt M E, Shen P F, Iacobelli S, Liu F T (Jan. 2001). "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation". Int. J. Cancer (UNITED STATES) 91 (2): 167–72. doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1022>3.3.CO;2-Q. ISSN 0020-7136. PMID 11146440.

[edit] Further reading

Nakahara S, Oka N, Raz A (2005). "On the role of galectin-3 in cancer apoptosis.". Apoptosis 10 (2): 267–75. doi:10.1007/s10495-005-0801-y. PMID 15843888.
Fukumori T, Kanayama HO, Raz A (2007). "The role of galectin-3 in cancer drug resistance.". Drug Resist. Updat. 10 (3): 101–8. doi:10.1016/j.drup.2007.04.001. PMID 17544840.

This article on a gene on chromosome 14 is a stub. You can help Wikipedia by expanding it.

[pmid2009535-0] Raz A, Carmi P, Raz T, Hogan V, Mohamed A, Wolman SR (May 1991). "Molecular cloning and chromosomal mapping of a human galactoside-binding protein". Cancer Res 51 (8): 2173–8. PMID 2009535.

[pmid8063692-1] Barondes SH, Cooper DN, Gitt MA, Leffler H (Sep 1994). "Galectins. Structure and function of a large family of animal lectins". J Biol Chem 269 (33): 20807–10. PMID 8063692.

[2] "Entrez Gene: LGALS3 lectin, galactoside-binding, soluble, 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3958.

[pmid19067971-3] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

[pmid1917996-4] Rosenberg, I; Cherayil B J, Isselbacher K J, Pillai S (Oct. 1991). "Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin". J. Biol. Chem. (UNITED STATES) 266 (28): 18731–6. ISSN 0021-9258. PMID 1917996.

[pmid8390986-5] Koths, K; Taylor E, Halenbeck R, Casipit C, Wang A (Jul. 1993). "Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain". J. Biol. Chem. (UNITED STATES) 268 (19): 14245–9. ISSN 0021-9258. PMID 8390986.

[pmid11146440-6] Tinari, N; Kuwabara I, Huflejt M E, Shen P F, Iacobelli S, Liu F T (Jan. 2001). "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation". Int. J. Cancer (UNITED STATES) 91 (2): 167–72. doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1022>3.3.CO;2-Q. ISSN 0020-7136. PMID 11146440.

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LGALS3

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[edit] Interactions

[edit] See also

[edit] References

[edit] Further reading

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