MED13

MED13
Identifiers
Aliases	MED13, ARC250, DRIP250, HSPC221, THRAP1, TRAP240, mediator complex subunit 13, MRD61
External IDs	OMIM: 603808; MGI: 3029632; HomoloGene: 21067; GeneCards: MED13; OMA:MED13 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q23.2 Start 61,942,605 bp End 62,065,278 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 C Start 86,157,859 bp End 86,248,428 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell visceral pleura germinal epithelium dorsal motor nucleus of vagus nerve secondary oocyte mucosa of paranasal sinus parietal pleura buccal mucosa cell tibia pylorus Top expressed in hand pineal gland genital tubercle tail of embryo otolith organ mesenteric lymph nodes utricle retinal pigment epithelium medial ganglionic eminence Rostral migratory stream More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator activity transcription coregulator activity thyroid hormone receptor binding nuclear receptor coactivator activity vitamin D receptor binding signaling receptor activity Cellular component membrane mediator complex nucleus nucleoplasm Biological process androgen receptor signaling pathway regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II intracellular steroid hormone receptor signaling pathway transcription, DNA-templated positive regulation of transcription, DNA-templated cholesterol homeostasis transcription initiation from RNA polymerase II promoter triglyceride homeostasis positive regulation of transcription by RNA polymerase II negative regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9969 327987 Ensembl ENSG00000108510 ENSMUSG00000034297 UniProt Q9UHV7 Q5SWW4 RefSeq (mRNA) NM_005121 NM_001080931 RefSeq (protein) NP_005112 NP_001074400 Location (UCSC) Chr 17: 61.94 – 62.07 Mb Chr 11: 86.16 – 86.25 Mb PubMed search
Wikidata
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Mediator complex subunit 13 is a protein that in humans is encoded by the MED13 gene.

Function

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.

Further reading

• Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J, Roeder RG (Jan 1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Molecular Cell. 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
• Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM (Feb 2010). "CDK8 is a positive regulator of transcriptional elongation within the serum response network". Nature Structural & Molecular Biology. 17 (2): 194–201. doi:10.1038/nsmb.1752. PMC 2920286. PMID 20098423.
• Näär AM, Taatjes DJ, Zhai W, Nogales E, Tjian R (Jun 2002). "Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation". Genes & Development. 16 (11): 1339–44. doi:10.1101/gad.987602. PMC 186316. PMID 12050112.
• Fondell JD, Ge H, Roeder RG (Aug 1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proceedings of the National Academy of Sciences of the United States of America. 93 (16): 8329–33. Bibcode:1996PNAS...93.8329F. doi:10.1073/pnas.93.16.8329. PMC 38670. PMID 8710870.
• Zhang X, Krutchinsky A, Fukuda A, Chen W, Yamamura S, Chait BT, Roeder RG (Jul 2005). "MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription". Molecular Cell. 19 (1): 89–100. doi:10.1016/j.molcel.2005.05.015. PMID 15989967.
• Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S (Aug 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene. 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. PMID 15208681.
• Gustafsson CM, Samuelsson T (Jul 2001). "Mediator--a universal complex in transcriptional regulation". Molecular Microbiology. 41 (1): 1–8. doi:10.1046/j.1365-2958.2001.02481.x. PMID 11454195. S2CID 30224146.
• Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
• Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proceedings of the National Academy of Sciences of the United States of America. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.