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Putative ribosomal RNA methyltransferase NOP2 is an enzyme that in humans is encoded by the NOP2gene.[5][6]
The protein encoded by this gene is a nucleolarantigen expressed in proliferating cells. It is not detectable in non-proliferating normal tissue but is detectable in many human tumors.[7]
Overexpression of p120 leads to malignant transformation of 3T3 cells while treatment with antisense p120 mRNA causes the transformed cells to revert to their original non-malignant phenotype.[8] The p120 protein displays a dramatic increase in expression at the G1/S transition suggesting that p120 regulates the cell cycle and nucleolar activity that is required for cell proliferation.[9]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Baens M, Chaffanet M, Aerssens J, Cassiman JJ, Marynen P (October 1994). "Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids". Genomics. 21 (1): 296–7. doi:10.1006/geno.1994.1267. PMID8088812.
^Fonagy A, Swiderski C, Wilson A, Bolton W, Kenyon N, Freeman JW (January 1993). "Cell cycle regulated expression of nucleolar antigen P120 in normal and transformed human fibroblasts". J. Cell. Physiol. 154 (1): 16–27. doi:10.1002/jcp.1041540104. PMID8419402. S2CID45238441.
Busch H (1990). "The final common pathway of cancer". Cancer Res. 50 (16): 4830–8. PMID2199030.
Valdez BC, Perlaky L, Saijo Y, Henning D, Zhu C, Busch RK, Zhang WW, Busch H (1992). "A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation". Cancer Res. 52 (20): 5681–6. PMID1394192.
Larson RG, Henning D, Haidar MA, Jhiang S, Lin WL, Zhang WW, Busch H (1990). "Genomic structure of the human proliferating cell nucleolar protein P120". Cancer Commun. 2 (2): 63–71. doi:10.3727/095535490820874704. PMID2372471.
Fonagy A, Henning D, Jhiang S, Haidar M, Busch RK, Larson R, Valdez B, Busch H (1989). "Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120". Cancer Commun. 1 (4): 243–51. PMID2576976.
Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H (1988). "Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase". Cancer Res. 48 (5): 1244–51. PMID3422591.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID16964243. S2CID14294292.