PEF1

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Penta-EF-hand domain containing 1
Identifiers
Symbols PEF1 ; ABP32; PEF1A
External IDs OMIM610033 MGI1915148 HomoloGene56569 GeneCards: PEF1 Gene
RNA expression pattern
PBB GE PEF1 217923 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 553115 67898
Ensembl ENSG00000162517 ENSMUSG00000028779
UniProt Q9UBV8 Q8BFY6
RefSeq (mRNA) NM_012392 NM_026441
RefSeq (protein) NP_036524 NP_080717
Location (UCSC) Chr 1:
32.1 – 32.11 Mb
Chr 4:
130.1 – 130.13 Mb
PubMed search [1] [2]

Peflin is a protein that in humans is encoded by the PEF1 gene.[1][2][3]

PEF1 is a Ca(2+)-binding protein that belongs to the penta-EF hand (PEF) protein family, which includes the calpain small subunit (CAPNS1; MIM 114170), sorcin (SRI; MIM 182520), grancalcin (GCA; MIM 607030), and ALG2 (PDCD6; MIM 601057) (Kitaura et al., 2001).[supplied by OMIM][3]

Interactions[edit]

PEF1 has been shown to interact with PDCD6.[4]

References[edit]

  1. ^ Kitaura Y, Watanabe M, Satoh H, Kawai T, Hitomi K, Maki M (Oct 1999). "Peflin, a novel member of the five-EF-hand-protein family, is similar to the apoptosis-linked gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region". Biochem Biophys Res Commun 263 (1): 68–75. doi:10.1006/bbrc.1999.1189. PMID 10486255. 
  2. ^ Kitaura Y, Satoh H, Takahashi H, Shibata H, Maki M (Mar 2002). "Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions". Arch Biochem Biophys 399 (1): 12–8. doi:10.1006/abbi.2001.2736. PMID 11883899. 
  3. ^ a b "Entrez Gene: PEF1 penta-EF-hand domain containing 1". 
  4. ^ Kitaura, Y; Matsumoto S; Satoh H; Hitomi K; Maki M (Apr 2001). "Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner". J. Biol. Chem. (United States) 276 (17): 14053–8. doi:10.1074/jbc.M008649200. ISSN 0021-9258. PMID 11278427. 

Further reading[edit]