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Penta-EF-hand domain containing 1
Symbols PEF1 ; ABP32; PEF1A
External IDs OMIM610033 MGI1915148 HomoloGene56569 GeneCards: PEF1 Gene
RNA expression pattern
PBB GE PEF1 217923 at tn.png
More reference expression data
Species Human Mouse
Entrez 553115 67898
Ensembl ENSG00000162517 ENSMUSG00000028779
UniProt Q9UBV8 Q8BFY6
RefSeq (mRNA) NM_012392 NM_026441
RefSeq (protein) NP_036524 NP_080717
Location (UCSC) Chr 1:
32.1 – 32.11 Mb
Chr 4:
130.1 – 130.13 Mb
PubMed search [1] [2]

Peflin is a protein that in humans is encoded by the PEF1 gene.[1][2][3]

PEF1 is a Ca(2+)-binding protein that belongs to the penta-EF hand (PEF) protein family, which includes the calpain small subunit (CAPNS1; MIM 114170), sorcin (SRI; MIM 182520), grancalcin (GCA; MIM 607030), and ALG2 (PDCD6; MIM 601057) (Kitaura et al., 2001).[supplied by OMIM][3]


PEF1 has been shown to interact with PDCD6.[4]


  1. ^ Kitaura Y, Watanabe M, Satoh H, Kawai T, Hitomi K, Maki M (Oct 1999). "Peflin, a novel member of the five-EF-hand-protein family, is similar to the apoptosis-linked gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region". Biochem Biophys Res Commun 263 (1): 68–75. doi:10.1006/bbrc.1999.1189. PMID 10486255. 
  2. ^ Kitaura Y, Satoh H, Takahashi H, Shibata H, Maki M (Mar 2002). "Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions". Arch Biochem Biophys 399 (1): 12–8. doi:10.1006/abbi.2001.2736. PMID 11883899. 
  3. ^ a b "Entrez Gene: PEF1 penta-EF-hand domain containing 1". 
  4. ^ Kitaura, Y; Matsumoto S; Satoh H; Hitomi K; Maki M (Apr 2001). "Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner". J. Biol. Chem. (United States) 276 (17): 14053–8. doi:10.1074/jbc.M008649200. ISSN 0021-9258. PMID 11278427. 

Further reading[edit]