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SC65

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P3H4
Identifiers
AliasesP3H4, NO55, NOL55, SC65, LEPREL4, prolyl 3-hydroxylase family member 4 (non-enzymatic), prolyl 3-hydroxylase family member 4 (inactive)
External IDsOMIM: 617419; MGI: 1913430; HomoloGene: 4713; GeneCards: P3H4; OMA:P3H4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006455

NM_176830
NM_001378981

RefSeq (protein)

NP_006446

NP_789800
NP_001365910

Location (UCSC)Chr 17: 41.8 – 41.81 MbChr 11: 100.3 – 100.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptonemal complex protein SC65, also known as Leprecan-like protein 4 (LEPREL4) or nucleolar autoantigen No55, is a protein that in humans is encoded by the LEPREL4 gene.[5]

Function

This nucleolar protein was first characterized because it was an autoantigen in cases on interstitial cystitis. The protein, with a predicted molecular weight of 50 kDa, appears to be localized in the particulate compartment of the interphase nucleolus, with a distribution distinct from that of nucleolar protein B23. During mitosis it is associated with chromosomes.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141696Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006931Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SC65 synaptonemal complex protein SC65".

Further reading