SEPT8

SEPTIN8
Identifiers
Aliases	SEPTIN8, SEP2, septin 8, SEPT8
External IDs	OMIM: 608418 MGI: 894310 HomoloGene: 57205 GeneCards: SEPTIN8
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,807,241 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	53,440,392 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; corpus callosum; ; inferior ganglion of vagus nerve; ; postcentral gyrus; ; entorhinal cortex; ; subthalamic nucleus; ; substantia nigra; ; superior frontal gyrus;
	Top expressed in
	facial motor nucleus; ; visual cortex; ; superior frontal gyrus; ; interventricular septum; ; cerebellar cortex; ; Region I of hippocampus proper; ; primary motor cortex; ; anterior horn of spinal cord; ; temporal lobe; ; piriform cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; GTPase activity; molecular adaptor activity;
Cellular component	cytoplasm; cytoskeleton; septin ring; microtubule cytoskeleton; septin complex; septin filament array; presynapse; membrane; cell junction; axon; synaptic vesicle membrane; cytoplasmic vesicle; cell projection; synapse;
Biological process	mitotic cytokinesis; septin ring assembly; cilium assembly; regulation of SNARE complex assembly; cytoskeleton-dependent cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	23176
	20362
	ENSG00000164402
	ENSMUSG00000018398
	Q92599
	Q8CHH9
NM_001098811; NM_001098812; NM_001098813; NM_001300798; NM_001300799;
	NM_015146
NM_001252332; NM_001252333; NM_033144; NM_001347496; NM_001361968;
	NM_001361969
NP_001092281; NP_001092282; NP_001092283; NP_001287727; NP_001287728;
	NP_055961
NP_001239261; NP_001239262; NP_001334425; NP_149156; NP_001348897;
	NP_001348898
	Wikidata
View/Edit Human	View/Edit Mouse

Septin-8 is a protein that in humans is encoded by the SEPT8 gene.^[5]^[6]^[7]

Function[edit]

SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking.^[7]

Interactions[edit]

SEPT8 has been shown to interact with PFTK1^[8] and SEPT5.^[9]^[10]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164402 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018398 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
^ Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM (May 1997). "Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region". Genome Research. 7 (5): 495–512. doi:10.1101/gr.7.5.495. PMID 9149945.
^ ^a ^b "Entrez Gene: SEPT8 septin 8".
^ Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780.
^ Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
^ Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038. S2CID 30822245.

Further reading[edit]

Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Wenderfer SE, Slack JP, McCluskey TS, Monaco JJ (February 2000). "Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11". Genomics. 63 (3): 354–73. doi:10.1006/geno.1999.6100. PMID 10704283.
Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038. S2CID 30822245.
Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780.
Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, Petty EM, Peifer M, Pringle JR, Robinson PJ, Roth D, Russell SE, Stuhlmann H, Tanaka M, Tanaka T, Trimble WS, Ware J, Zeleznik-Le NJ, Zieger B (December 2002). "Mammalian septins nomenclature". Molecular Biology of the Cell. 13 (12): 4111–3. doi:10.1091/mbc.E02-07-0438. PMC 138619. PMID 12475938.
Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B (May 2004). "The novel human platelet septin SEPT8 is an interaction partner of SEPT4". Thrombosis and Haemostasis. 91 (5): 959–66. doi:10.1160/TH03-09-0578. PMID 15116257. S2CID 22853459.
Martínez C, Sanjuan MA, Dent JA, Karlsson L, Ware J (September 2004). "Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol". The Biochemical Journal. 382 (Pt 3): 783–91. doi:10.1042/BJ20040372. PMC 1133953. PMID 15214843.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Bläser S, Röseler S, Rempp H, Bartsch I, Bauer H, Lieber M, Lessmann E, Weingarten L, Busse A, Huber M, Zieger B (September 2006). "Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5". The Journal of Pathology. 210 (1): 103–10. doi:10.1002/path.2013. PMID 16767699. S2CID 45797279.
Xin X, Pache M, Zieger B, Bartsch I, Prünte C, Flammer J, Meyer P (November 2007). "Septin expression in proliferative retinal membranes". The Journal of Histochemistry and Cytochemistry. 55 (11): 1089–94. doi:10.1369/jhc.7A7188.2007. PMC 3957527. PMID 17625225.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164402 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018398 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9039502-5] Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.

[pmid9149945-6] Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM (May 1997). "Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region". Genome Research. 7 (5): 495–512. doi:10.1101/gr.7.5.495. PMID 9149945.

[entrez-7] "Entrez Gene: SEPT8 septin 8".

[pmid12098780-8] Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780.

[pmid12909369-9] Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.

[pmid12023038-10] Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038. S2CID 30822245.

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