Sjogren syndrome antigen B

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Sjogren syndrome antigen B (autoantigen La)
Protein SSB PDB 1owx.png
PDB rendering based on 1owx.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SSB ; LARP3; La; La/SSB
External IDs OMIM109090 MGI98423 HomoloGene2366 GeneCards: SSB Gene
RNA expression pattern
PBB GE SSB 201138 s at tn.png
PBB GE SSB 201139 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6741 20823
Ensembl ENSG00000138385 ENSMUSG00000068882
UniProt P05455 P32067
RefSeq (mRNA) NM_001294145 NM_001110145
RefSeq (protein) NP_001281074 NP_001103615
Location (UCSC) Chr 2:
170.65 – 170.67 Mb
Chr 2:
69.86 – 69.87 Mb
PubMed search [1] [2]
The correct title of this article is Sjögren syndrome antigen. It appears incorrectly here because of technical restrictions.

Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene.[1]

Function[edit]

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjögren's syndrome and systemic lupus erythematosus.[1][2]

Interactions[edit]

Sjögren syndrome antigen B has been shown to interact with nucleolin.[3]

References[edit]

  1. ^ a b "Entrez Gene: SSB Sjögren's syndrome antigen B (autoantigen La)". 
  2. ^ Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ (January 2006). "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen". Mol. Cell 21 (1): 75–85. doi:10.1016/j.molcel.2005.10.027. PMID 16387655. 
  3. ^ Fouraux, Michael A; Bouvet Philippe; Verkaart Sjoerd; van Venrooij Walther J; Pruijn Ger J M (July 2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". J. Mol. Biol. (England) 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. ISSN 0022-2836. PMID 12096904. 

Further reading[edit]