SEPSECS

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Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SEPSECS ; LP; PCH2D; SLA; SLA/LP
External IDs OMIM613009 MGI1098791 HomoloGene15031 GeneCards: SEPSECS Gene
EC number 2.9.1.2
Orthologs
Species Human Mouse
Entrez 51091 211006
Ensembl ENSG00000109618 ENSMUSG00000029173
UniProt Q9HD40 Q6P6M7
RefSeq (mRNA) NM_001159728 NM_172490
RefSeq (protein) NP_058651 NP_766078
Location (UCSC) Chr 4:
25.12 – 25.16 Mb
Chr 5:
52.64 – 52.67 Mb
PubMed search [1] [2]

O-phosphoseryl-tRNA(Sec) selenium transferase is an enzyme that in humans is encoded by the SEPSECS gene.[1][2][3][4][5]


References[edit]

  1. ^ Xu XM, Mix H, Carlson BA, Grabowski PJ, Gladyshev VN, Berry MJ, Hatfield DL (Dec 2005). "Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery". J Biol Chem 280 (50): 41568–75. doi:10.1074/jbc.M506696200. PMID 16230358. 
  2. ^ Costa M, Rodriguez-Sanchez JL, Czaja AJ, Gelpi C (Aug 2000). "Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from patients withtype-1 autoimmune hepatitis". Clin Exp Immunol 121 (2): 364–74. doi:10.1046/j.1365-2249.2000.01280.x. PMC 1905695. PMID 10931155. 
  3. ^ Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Soll D (Dec 2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proc Natl Acad Sci U S A 103 (50): 18923–7. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313. 
  4. ^ Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL (Apr 2007). "Biosynthesis of selenocysteine on its tRNA in eukaryotes". PLoS Biol 5 (1): e4. doi:10.1371/journal.pbio.0050004. PMC 1717018. PMID 17194211. 
  5. ^ "Entrez Gene: SLA/LP soluble liver antigen/liver pancreas antigen". 

Further reading[edit]