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Thrombospondin 2
Protein THBS2 PDB 1yo8.png
PDB rendering based on 1yo8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols THBS2 ; TSP2
External IDs OMIM188061 MGI98738 HomoloGene2438 GeneCards: THBS2 Gene
RNA expression pattern
PBB GE THBS2 203083 at tn.png
More reference expression data
Species Human Mouse
Entrez 7058 21826
Ensembl ENSG00000186340 ENSMUSG00000023885
UniProt P35442 Q03350
RefSeq (mRNA) NM_003247 NM_011581
RefSeq (protein) NP_003238 NP_035711
Location (UCSC) Chr 6:
169.62 – 169.65 Mb
Chr 17:
14.67 – 14.69 Mb
PubMed search [1] [2]

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.[1][2]

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.[2]


THBS2 has been shown to interact with MMP2.[3]


  1. ^ Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008). "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation". Am J Hum Genet 82 (5): 1122–9. doi:10.1016/j.ajhg.2008.03.013. PMC 2427305. PMID 18455130. 
  2. ^ a b "Entrez Gene: THBS2 thrombospondin 2". 
  3. ^ Bein, K; Simons M (October 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". J. Biol. Chem. (UNITED STATES) 275 (41): 32167–73. doi:10.1074/jbc.M003834200. ISSN 0021-9258. PMID 10900205. 

Further reading[edit]