T-cell vaccination

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T cell vaccination is immunization with inactivated autoreactive T cells. The concept of T cell vacination is, at least partially, analogous to classical vaccination against infectious disease. However, the agents to be eliminated or neutralized are not foreign microbial agents but a pathogenic autoreactive T cell population. Research on T cell vaccination so far has focused mostly on multiple sclerosis and to a lesser extent on rheumatoid arthritis, Crohn's disease and AIDS.[1][2][3]

To be distinguished from T-cell vaccines that are vaccines designed to induce protective T cells.

References[edit]

  1. ^ Cohen IR (2001). "T-cell vaccination for autoimmune disease: a panorama". Vaccine 20 (5–6): 706–10. doi:10.1016/S0264-410X(01)00419-4. PMID 11738733. 
  2. ^ Hellings N, Raus J, Stinissen P (2004). "T-cell vaccination in multiple sclerosis: update on clinical application and mode of action". Autoimmun Rev 3 (4): 267–75. doi:10.1016/j.autrev.2003.10.002. PMID 15246022. 
  3. ^ Zhang J (2002). "T-cell vaccination for autoimmune diseases: immunologic lessons and clinical experience in multiple sclerosis". Expert Rev Vaccines 1 (3): 285–92. doi:10.1586/14760584.1.3.285. PMID 12901569.