The July 27, 2005, front page of
David Ross Locke gained national fame for the paper during the Civil War era by writing under the pen name Petroleum V. Nasby. Writing under the pen name, Locke wrote satires ranging on topics from slavery to the Civil War to temperance. President Abraham Lincoln was fond of the Nasby satires and sometimes quoted them. In 1867 Locke bought The Blade.
In 2004 The Blade won the Pulitzer Prize for Investigative Reporting with a series of stories entitled "Buried Secrets, Brutal Truths". The story brought to light the story of the Tiger Force, a Vietnam fighting force that brutalized the local population. In 2006, The Blade was a finalist for a Pulitzer Prize, and winner of the National Headliner Award, for breaking the scandal in Ohio known as Coingate.
Its current editor in chief is John Robinson Block, whose family purchased the paper in 1926 and who also own the media conglomerate Block Communications, which owns cable systems, television stations, and an Internet service network, Buckeye Express.
According to a 2008 BurrellsLuce circulation report, The Blade has the 83rd largest daily newspaper circulation in the United States.
In 2007 Blade photojournalist Allan Detrich left the Blade when it was discovered that he had digitally altered a photo that was published on the front page of the March 31, 2007, edition. A subsequent investigation revealed that he had digitally altered and submitted 79 photos during the first 14 weeks of 2007, 58 of which ran either in The Blade or on its website.
Members of several unions worked without contracts from March to August 2006. Over the course of August 2006, The Blade locked out over 25% of all of its employees. The strike and lockout ended in May 2007.
Toledo Free Press lawsuit 
In October 2011, The Blade filed a lawsuit against rival publication the Toledo Free Press, claiming that former Blade general manager and current Free Press publisher Thomas F. Pounds violated a 2004 separation agreement containing a non-compete clause. In December 2011, the Free Press responded to the lawsuit and filed a counterclaim, asserting that Blade owners Block Communications were "attempting to exercise prior restraint" on the Free Press and that since the non-compete agreement expired in 2005, the Blade's use of it as a legal weapon in 2011 was "simply as a tool to economically harm" the Free Press and its publisher, and "well beyond the bounds of fair and legal competition."
According to the Free Press, The Blade took exception to an editorial cartoon criticizing The Blade's stance on downtown development plans by Rave Cinemas and Hollywood Casino Toledo; The Blade cited the cartoon among the grounds for its lawsuit: "On or about August 21, 2011, Pounds ... permitted Toledo Free Press to publish a cartoon that depicted a characterization of John R. Block and Allan Block together with The Blade as casting an eclipsing shadow on jobs, tax revenue, investment and development in Toledo, Ohio."
- "2008 Top 100 Daily Newspapers in the U.S. by Circulation" (PDF). BurrellesLuce. 2008-03-31. Retrieved 2009-04-06.
- With a clue (Metro Times Detroit)
- Winslow, Ron (2008-04-09). "Toledo Blade's Detrich Resigns Over Digitally Altered Photograph". News Photographer magazine (National Press Photographers Association). Retrieved 2008-05-12.
- Royhab, Ron (2008-04-15). "A basic rule: Newspaper photos must tell the truth". ToledoBlade.com. Retrieved 2008-05-12.
- "Blade, Unions reach a deal to end the lockout". The Bryan Times. May 24, 2007.
- "Blade's parent company sues ex-manager for contract breach". The Blade. October 21, 2011. Retrieved December 19, 2011.
- "TFP answers Blade lawsuit, files countersuits". Toledo Free Press. December 19, 2011. Retrieved December 19, 2011.
- Miller, Michael S. (October 28, 2011). "Was it something I said?". Toledo Free Press. Retrieved December 19, 2011.