TRNP1
TMF regulated nuclear protein 1 is a nuclear protein with a crucial role in brain development.[1] Trnp1 is the first protein that has been shown to play a major role in cortical folding.[1] It represents a major stem cell factor, that is involved in crucial processes during brain but also stem cell development. Trnp1 controls gene expression levels and is sufficient to induce gyri and sulci in the developing brain. Local differences of Trnp1 expression levels in the human brain correlate with cortical folding.[1][2][3]
References
- ^ a b c Stahl, Ronny; Walcher, Tessa; De Juan Romero, Camino; Pilz, Gregor Alexander; Cappello, Silvia; Irmler, Martin; Sanz-Aquela, José Miguel; Beckers, Johannes; Blum, Robert (2013-04-25). "Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral Cortex by Control of Radial Glial Fate". Cell. 153 (3): 535–549. doi:10.1016/j.cell.2013.03.027. ISSN 0092-8674. PMID 23622239.
{{cite journal}}: no-break space character in|last3=at position 3 (help) - ^ Fernández, Virginia; Llinares‐Benadero, Cristina; Borrell, Víctor (2016-04-07). "Cerebral cortex expansion and folding: what have we learned?". The EMBO Journal: e201593701. doi:10.15252/embj.201593701. ISSN 0261-4189. PMC 4868950. PMID 27056680.
- ^ Martínez-Martínez, Maria Ángeles; Romero, Camino De Juan; Fernández, Virginia; Cárdenas, Adrián; Götz, Magdalena; Borrell, Víctor (2016-06-06). "A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels". Nature Communications. 7. doi:10.1038/ncomms11812. ISSN 2041-1723. PMC 4897765. PMID 27264089.
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