Von Hippel–Lindau binding protein 1
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| von Hippel-Lindau binding protein 1 | |
|---|---|
| Identifiers | |
| Symbol | VBP1 |
| Entrez | 7411 |
| HUGO | 12662 |
| OMIM | 300133 |
| RefSeq | NM_003372 |
| UniProt | P61758 |
| Other data | |
| Locus | Chr. X q28 |
von Hippel–Lindau binding protein 1 (VBP1), also known as "prefoldin 3", is a chaperone protein that binds to von Hippel–Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell.[1] It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding.[2]
VBP1 is a 197–amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits,[2] and is a member of the prefoldin-α subunit family.[3] It is ubiquitously expressed in tissues, and is located in the cell in the nucleus and cytoplasm.[3] The VBP1 gene is located at Xq28.[4] Homologues are known to exist between human VBP1 and proteins in mice, Drosophila and C. elegans.[2]
[edit] See also
[edit] References
- ^ Tsuchiya H, Iseda T and Hino O (1996). "Identification of a novel protein (VBP-1) binding to the von Hippel–Lindau (VHL) tumor suppressor gene product". Cancer Research 56 (13): 2881–5. PMID 8674032.
- ^ a b c "GenAtlas report: VBP1". 2003-01-17. http://www.dsi.univ-paris5.fr/genatlas/fiche.php?symbol=VBP1. Retrieved 2007-07-17.
- ^ a b "NiceProt report: P61758 (Prefoldin 3, human)". 2007-07-10. http://www.expasy.org/cgi-bin/niceprot.pl?P61758. Retrieved 2007-07-17.
- ^ Brinke A, Green PM and Giannelli F (1997). "Characterization of the gene (VBP1) and transcript for the von Hippel–Lindau binding protein and isolation of the highly conserved murine homologue". Genomics 45 (1): 105–12. doi:10.1006/geno.1997.4902. PMID 9339366.
[edit] External links
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