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WAP four-disulfide core domain protein 5 is a protein that in humans is encoded by the WFDC5gene.[5][6][7]
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.[7]
^Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR (Mar 2000). "The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling". J Mol Graph Model. 17 (2): 106–13, 134–6. doi:10.1016/S1093-3263(99)00023-6. PMID10680116.
Horikoshi N, Cong J, Kley N, Shenk T (1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene". Biochem. Biophys. Res. Commun. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID10441517.