Xylulose 5-phosphate
| |
| Identifiers | |
|---|---|
3D model (JSmol)
|
|
| ChEBI | |
| ChemSpider | |
| MeSH | xylulose-5-phosphate |
PubChem CID
|
|
| |
| |
| Properties | |
| C5H11O8P | |
| Molar mass | 230.109 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
D-Xylulose 5-phosphate (D-xylulose-5-P) is an intermediate in the pentose phosphate pathway. It is a ketose sugar formed from ribulose-5-phosphate. Although previously thought of mainly as an intermediary in the pentose phosphate pathway, recent research reported that the sugar has a role in gene expression, mainly by promoting the ChREBP transcription factor in the well-fed state.[1][2] However, more recent study showed that D-glucose-6-phosphate, rather than D-xylulose-5-phosphate, is essential for the activation of ChREBP in response to glucose.[3]
References
- ^ Kabashima, T.; Kawaguchi, T.; Wadzinski, B. E.; Uyeda, K. (2003). "Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver". Proceedings of the National Academy of Sciences. 100 (9): 5107–5112. Bibcode:2003PNAS..100.5107K. doi:10.1073/pnas.0730817100. PMC 154306. PMID 12684532.
- ^ Iizuka K, Horikawa Y (August 2008). "ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome". Endocr. J. 55 (4): 617–24. doi:10.1507/endocrj.k07e-110. PMID 18490833.
- ^ Dentin, Renaud; Tomas-Cobos, Lidia; Foufelle, Fabienne; Leopold, Jane; Girard, Jean; Postic, Catherine; Ferré, Pascal (2012). "Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver". Journal of Hepatology. 56 (1): 199–209. doi:10.1016/j.jhep.2011.07.019. PMID 21835137.
.svg){kind=small} | This biochemistry article is a stub. You can help Wikipedia by expanding it. |