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Yoshizumi Ishino

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Yoshizumi Ishino
石野 良純
Born1959
Kyoto Prefecture, Japan
NationalityJapanese
Alma materOsaka University
Known forCRISPR
AwardsAMED Award (2017)
Scientific career
FieldsMolecular biology
Biotechnology
InstitutionsKyushu University
University of Illinois at Urbana–Champaign

Yoshizumi Ishino (石野 良純, Ishino Yoshizumi) is a Japanese molecular biologist, known for his discovering the DNA sequence of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR).

Biography

Ishino was born in Kyoto Prefecture, Japan. He received his BS, MS and PhD in 1981, 1983 and 1986, respectively, from Osaka University.[1] From 1987 to 1989, he served as a post-doctoral fellow in Dieter Söll's laboratory at Yale University.[2]

In 2002, he became a professor at Kyushu University.[3][4] Since October 2013, he has been a member of the NASA Astrobiology Institute, University of Illinois at Urbana–Champaign.[5]

After completing his PhD, Ishino became senior research scientist at the Bioproducts Development Center of Takara Shuzo. Later in life, he joined BERI (Biomolecular Engineering Research Institute), in which he conducted research on nucleic acids-related enzymes.[4]

Research contribution

Ishino has contributed to the development of enzymology and nucleic acids research in his life. The "iap" gene in gut microbe E. coli was sequenced by Ishino and his colleagues in 1987.[6] As the DNA segment used was longer than the gene itself, they accidentally discovered a partial DNA sequence of then-unnamed CRISPR in the process,[7] which would eventually become the basis of CRISPR gene editing. Ishino was one of the first scientists to have detected CRISPRs in E. coli.[8] In 1990, Ishino began researching DNA replication of micro-organisms in the Archaea domain.[9]

Recognition

References

  1. ^ Yoshizumi Ishino | astrobiology.illinois.edu Archived September 30, 2015, at the Wayback Machine
  2. ^ Bioresource, Yoshizumi IshinoKyushu University; D, Bioenvironmental Sciences 43 19 · Ph. "Yoshizumi Ishino - Ph D - Kyushu University, Fukuoka - Kyudai - Graduate School of Bioresource and Bioenvironmental Sciences". Researchgate.net. Retrieved 29 October 2018.{{cite web}}: CS1 maint: numeric names: authors list (link)
  3. ^ "Kaken - 石野 良純(30346837)". kaken.nii.ac.jp. Archived from the original on 29 September 2015. Retrieved 3 February 2022.
  4. ^ a b "Yoshizumi Ishino". astrobiology.illinois.edu. Retrieved 2018-12-02.
  5. ^ "九州大学-研究者情報 [石野 良純 (教授) 農学研究院 生命機能科学部門]". Hyoka.ofc.kyushu-u.ac.jp. Retrieved 29 October 2018.
  6. ^ "CRISPR Natural History in Bacteria". Quanta Magazine. Retrieved 2019-04-01.
  7. ^ Ishino Y, Shinagawa H, Makino K, Amemura M, Nakata A (1987). "Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product". J Bacteriol. 169 (12): 5429–33. doi:10.1128/jb.169.12.5429-5433.1987. PMC 213968. PMID 3316184.
  8. ^ Forterre, Patrick; Krupovic, Mart; Ishino, Yoshizumi (2018-04-01). "History of CRISPR-Cas from Encounter with a Mysterious Repeated Sequence to Genome Editing Technology". Journal of Bacteriology. 200 (7): e00580–17. doi:10.1128/JB.00580-17. ISSN 0021-9193. PMC 5847661. PMID 29358495.
  9. ^ "Dr. Yoshizumi Ishino - CRISPR | Feb 11, 2019". www.targethealth.com. Retrieved 2019-04-01.

Further reading

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