Zinc finger protein 536

ZNF536
Identifiers
Aliases	ZNF536, zinc finger protein 536
External IDs	OMIM: 618037; MGI: 1926102; HomoloGene: 8813; GeneCards: ZNF536; OMA:ZNF536 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	30,713,538 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	37,773,641 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; retinal pigment epithelium; ; corpus callosum; ; inferior ganglion of vagus nerve; ; cerebellar vermis; ; sural nerve; ; Pons; ; Medulla Oblongata; ; C1 segment; ; Brodmann area 46;
	Top expressed in
	epithelium of lens; ; neural layer of retina; ; retinal pigment epithelium; ; sciatic nerve; ; ciliary body; ; lumbar subsegment of spinal cord; ; ventricular zone; ; Rostral migratory stream; ; iris; ; pelvic ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; retinoic acid-responsive element binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	negative regulation of retinoic acid receptor signaling pathway; multicellular organism development; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; negative regulation of neuron differentiation; signal transduction; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	9745
	243937
	ENSG00000198597
	ENSMUSG00000043456
	O15090
	Q8K083
	NM_014717; NM_001352260; NM_001376110; NM_001376111
	NM_172385
	NP_055532; NP_001339189; NP_001363039; NP_001363040
NP_759017; NP_001391020; NP_001391022; NP_001391023; NP_001391024;
	NP_001391025; NP_001391026; NP_001391028; NP_001391029
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 536 is a protein that in humans is encoded by the ZNF536 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198597 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043456 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Zinc finger protein 536".

Qin Z, Ren F, Xu X, Ren Y, Li H, Wang Y, Zhai Y, Chang Z (July 2009). "ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription". Molecular and Cellular Biology. 29 (13): 3633–43. doi:10.1128/MCB.00362-09. PMC 2698762. PMID 19398580.
Dugas JC, Tai YC, Speed TP, Ngai J, Barres BA (October 2006). "Functional genomic analysis of oligodendrocyte differentiation". The Journal of Neuroscience. 26 (43): 10967–83. doi:10.1523/JNEUROSCI.2572-06.2006. PMC 6674672. PMID 17065439.
Benjamin EJ, Dupuis J, Larson MG, Lunetta KL, Booth SL, Govindaraju DR, Kathiresan S, Keaney JF, Keyes MJ, Lin JP, Meigs JB, Robins SJ, Rong J, Schnabel R, Vita JA, Wang TJ, Wilson PW, Wolf PA, Vasan RS (September 2007). "Genome-wide association with select biomarker traits in the Framingham Heart Study". BMC Medical Genetics. 8 Suppl 1: S11. doi:10.1186/1471-2350-8-S1-S11. PMC 1995615. PMID 17903293.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Low SK, Chung S, Takahashi A, Zembutsu H, Mushiroda T, Kubo M, Nakamura Y (August 2013). "Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan". Cancer Science. 104 (8): 1074–82. doi:10.1111/cas.12186. PMC 7657179. PMID 23648065. S2CID 5954226.
Meng W, Butterworth J, Bradley DT, Hughes AE, Soler V, Calvas P, Malecaze F (December 2012). "A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population". Investigative Ophthalmology & Visual Science. 53 (13): 7983–8. doi:10.1167/iovs.12-10409. PMID 23049088.
Sakai T, Hino K, Wada S, Maeda H (August 2003). "Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor". DNA Research. 10 (4): 155–65. doi:10.1093/dnares/10.4.155. PMID 14621294.
Seppälä I, Kleber ME, Lyytikäinen LP, Hernesniemi JA, Mäkelä KM, Oksala N, Laaksonen R, Pilz S, Tomaschitz A, Silbernagel G, Boehm BO, Grammer TB, Koskinen T, Juonala M, Hutri-Kähönen N, Alfthan G, Viikari JS, Kähonen M, Raitakari OT, März W, Meinitzer A, Lehtimäki T (February 2014). "Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality". European Heart Journal. 35 (8): 524–31. doi:10.1093/eurheartj/eht447. PMID 24159190.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198597 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043456 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger protein 536".

[1]

[2]

[3]

[4]

[5]

References

Further reading