Intraneural perineurioma
An intraneural perineurioma is a rare benign tumor within the sheath of a single nerve that grows but typically does not recur or metastasize. These lesions are only composed of perineurial cells, cloned from a single cell. They are distinct from schwannoma and neurofibroma.
Intraneural perineurioma is a neoplastic proliferation of perineurial cells with unique immunohistochemistry and ultrastructural features, and it is distinct from other onion bulb Schwann cell-derived entities. Despite harboring molecular abnormalities of the long arm of chromosome 22, intraneural perineurioma has not been associated with neurofibromatosis.[1]
Due to the involvement of one or more nerve fascicles, intraneural perineuriomas are distinguished by a localized, solitary expansion of peripheral nerves. These tumors develop slowly or stay stable over time.[2]
References
[edit]- ^ Boyanton BL Jr; Jones JK; Shenaq SM; Hicks MJ; Bhattacharjee MB (2007). "Intraneural perineurioma: a systematic review with illustrative cases". Archives of Pathology & Laboratory Medicine. 131 (9): 1382–92. doi:10.5858/2007-131-1382-IPASRW. PMID 17824794.
- ^ Mauermann, M. L.; Amrami, K. K.; Kuntz, N. L.; Spinner, R. J.; Dyck, P. J.; Bosch, E. P.; Engelstad, J.; Felmlee, J. P.; Dyck, P. J. (2009). "Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth". Brain. 132 (Pt 8): 2265–2276. doi:10.1093/brain/awp169. PMC 2724918. PMID 19567701.
Further reading
[edit]- Macarenco RS, Ellinger F, Oliveira AM (2007). "Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm". Archives of Pathology & Laboratory Medicine. 131 (4): 625–36. doi:10.5858/2007-131-625-PADAUP. PMID 17425397.
- Kum YS, Kim JK, Cho CH, Kim HK (2009). "Intraneural reticular perineurioma of the hypoglossal nerve". Head & Neck. 31 (6): 833–7. doi:10.1002/hed.20965. PMID 18972430. S2CID 19616068.
- Chung JH, Jeong SH, Dhong ES, Han SK (2014). "Surgical removal of intraneural perineurioma arising in the brachial plexus using an interfascicular dissection technique". Arch Plast Surg. 41 (3): 296–9. doi:10.5999/aps.2014.41.3.296. PMC 4037780. PMID 24883285.
- Emory TS, Scheithauer BW, Hirose T, Wood M, Onofrio BM, Jenkins RB (1995). "Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22". Am J Clin Pathol. 103 (6): 696–704. doi:10.1093/ajcp/103.6.696. PMID 7785653.