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Chemical compound
Valperinol ATC code Legal status
In general: non-regulated
(1R ,3R ,4S ,6R ,7S ,8R ,10R )-8-methoxy-10-methyl-3-(1-piperidinylmethyl)-2,9-dioxatricyclo[4.3.1.03,7 ]decan-4-ol
CAS Number PubChem CID ChemSpider UNII Formula C 16 H 27 N O 4 Molar mass 297.395 g·mol−1 3D model (JSmol )
O1[C@@H](OC)[C@@H]2[C@@]3(O[C@H]1[C@@H]([C@H]2C[C@@H]3O)C)CN4CCCCC4
InChI=1S/C16H27NO4/c1-10-11-8-12(18)16(9-17-6-4-3-5-7-17)13(11)15(19-2)20-14(10)21-16/h10-15,18H,3-9H2,1-2H3/t10-,11-,12+,13-,14+,15-,16-/m1/s1
Key:KZSHXABWNBVUTK-GBIHRFPISA-N
Valperinol (INN ; GA 30-905 ) is a drug which acts as a calcium channel blocker .[1] [2] It was patented as a possible sedative , antiepileptic , and/or antiparkinsonian agent, but was never marketed.[3]
References [ edit ]
^ Thies PW, Asai A, Bán I, David S, Finner E (1984). "[The synthesis of valperinol and various 3-aminomethyl derivatives of 2,9-dioxatricyclo[4,3,1,0(3,7)]decane from didrovaltrate]". Arzneimittel-Forschung (in German). 34 (11): 1460–3. PMID 6543120 .
^ Dose M (1984). "[Calcium antagonist properties of valperinol]". Arzneimittel-Forschung (in German). 34 (11): 1464–6. PMID 6098282 .
^ Dictionary of Pharmacological Agents Volume 2 . CRC Press. 1996-11-21. p. 2104. ISBN 978-0-412-46630-4 . Retrieved 22 April 2012 .
Calcium
VDCCs Tooltip Voltage-dependent calcium channels
Potassium
VGKCs Tooltip Voltage-gated potassium channels
IRKs Tooltip Inwardly rectifying potassium channel
KCa Tooltip Calcium-activated potassium channel
K2Ps Tooltip Tandem pore domain potassium channel
Sodium
VGSCs Tooltip Voltage-gated sodium channels
ENaC Tooltip Epithelial sodium channel
ASICs Tooltip Acid-sensing ion channel
Chloride
CaCCs Tooltip Calcium-activated chloride channel
CFTR Tooltip Cystic fibrosis transmembrane conductance regulator
Unsorted
Others
TRPs Tooltip Transient receptor potential channels LGICs Tooltip Ligand gated ion channels