Sex differences in medicine: Difference between revisions
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* [[Prostate cancer]], [[testicular cancer]] and other diseases of the male reproductive system occur in [[men]].<ref name="MNT">{{cite web |title=Prostate vs. testicular cancer: Similarities and differences |url=https://www.medicalnewstoday.com/articles/testicular-cancer-vs-prostate-cancer |website=Medical News Today |access-date=10 November 2021 |language=en |date=25 October 2021}}</ref> |
* [[Prostate cancer]], [[testicular cancer]] and other diseases of the male reproductive system occur in [[men]].<ref name="MNT">{{cite web |title=Prostate vs. testicular cancer: Similarities and differences |url=https://www.medicalnewstoday.com/articles/testicular-cancer-vs-prostate-cancer |website=Medical News Today |access-date=10 November 2021 |language=en |date=25 October 2021}}</ref> |
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* Diseases of [[X-linked recessive inheritance]], such as [[color blindness|colour blindness]], occur more frequently in men, and [[haemophilia]] A and B occur almost exclusively in men.<ref>{{cite web|url=https://www.nlm.nih.gov/medlineplus/hemophilia.html|title=U.S. National Library of Medicine|archive-url=https://web.archive.org/web/20071012095806/http://www.nlm.nih.gov/medlineplus/hemophilia.html|archive-date=12 October 2007|url-status=live|access-date=2 December 2007}}</ref> |
* Diseases of [[X-linked recessive inheritance]], such as [[color blindness|colour blindness]], occur more frequently in men, and [[haemophilia]] A and B occur almost exclusively in men.<ref>{{cite web|url=https://www.nlm.nih.gov/medlineplus/hemophilia.html|title=U.S. National Library of Medicine|archive-url=https://web.archive.org/web/20071012095806/http://www.nlm.nih.gov/medlineplus/hemophilia.html|archive-date=12 October 2007|url-status=live|access-date=2 December 2007}}</ref> |
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* The presence of a single X chromosome in males may mean that they are more susceptible to genetic diseases linked to the X chromosome,<ref>{{cite journal |last1=Migeon |first1=Barbara R. |title=Why females are mosaics, x-chromosome inactivation, and sex differences in disease |journal=Gender Medicine |date=June 2007 |volume=4 |issue=2 |pages=97–105 |doi=10.1016/S1550-8579(07)80024-6 |url=https://www.researchgate.net/publication/6131777_Why_females_are_mosaics_X-chromosome_inactivation_and_sex_differences_in_disease |access-date=11 November 2021}}</ref><ref name="Brown">{{cite journal |last1=Brown |first1=Carolyn |title=Patchwork women |journal=Nature Genetics |date=September 2007 |volume=39 |issue=9 |pages=1043–1043 |doi=10.1038/ng0907-1043 |url=https://doi.org/10.1038/ng0907-1043 |access-date=11 November 2021 |language=en |issn=1546-1718}}</ref><ref name="Migeon">{{cite book |last1=Migeon |first1=Barbara R. |title=Females are mosaics : X inactivation and sex differences in disease |date=2014 |publisher=Oxford University Press |location=Oxford |isbn=9780199927531 |edition=Second}}</ref> such as [[Duchenne muscular dystrophy]]. [[hemophilia]] and [[Hunter syndrome]].<ref name="Doblhammer">{{cite book |last1=Doblhammer |first1=Gabriele |last2=Gumà |first2=Jordi |title=A Demographic Perspective on Gender, Family and Health in Europe |date=February 12, 2018 |publisher=Springer |isbn=978-1013269073 |page=78 |url=https://books.google.com/books?id=MuBLDwAAQBAJ&pg=PA78 |access-date=11 November 2021}}</ref> |
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* The [[neurodegenerative diseases]] [[Parkinson's disease]] and [[Lewy body dementia]] are more prevalent in men.<ref name="Zielonka"/> |
* The [[neurodegenerative diseases]] [[Parkinson's disease]] and [[Lewy body dementia]] are more prevalent in men.<ref name="Zielonka"/> |
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* [[Abdominal aortic aneurysm]]s are six times more common in men, and thus some countries have introduced screening for males at risk of suffering the condition.<ref name="aneurysm">{{cite news|title=Men to get aneurysm screening|url=http://news.bbc.co.uk/2/hi/health/7172094.stm|access-date=6 June 2016|work=BBC|date=5 January 2008}}</ref> |
* [[Abdominal aortic aneurysm]]s are six times more common in men, and thus some countries have introduced screening for males at risk of suffering the condition.<ref name="aneurysm">{{cite news|title=Men to get aneurysm screening|url=http://news.bbc.co.uk/2/hi/health/7172094.stm|access-date=6 June 2016|work=BBC|date=5 January 2008}}</ref> |
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Revision as of 17:45, 11 November 2021
| Part of a series on |
| Sex differences in humans |
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| Medicine and health |
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Sex differences in medicine include sex-specific diseases or conditions which occur only in people of one sex due to underlying biological factors (for example, prostate cancer in males or uterine cancer in females); sex-related diseases, which are diseases that are more common to one sex (for example, breast cancer and systemic lupus erythematosus which occur predominantly in females);[1] and diseases which occur at similar rates in males and females but manifest differently according to sex (for example, peripheral artery disease).[2]
Sex differences should not be confused with gender differences. The US National Academy of Medicine recognizes sex differences as biological at the chromosomal level, whereas gender differences are based on self-representation and other factors including biology, environment and experience.[3][4] That said, both biological and behavioural differences influence human health, and may do so differentially. Such factors can be inter-related and difficult to separate. Evidence-based approaches to sex and gender medicine try to examine the effects of both sex and gender as factors when dealing with medical conditions that may affect populations differently.[5] [3]
As of 2021[update] over 10,000 articles had been published addressing sex and gender differences in clinical medicine and related literature. Sex and gender affect "the cardiovascular, pulmonary and autoimmune systems, as well as diseases involving gastroenterology, hepatology, nephrology, endocrinology, haematology and neurology; they also influence pharmacokinetics and pharmacodynamics."[5][3]
Sexually transmitted diseases, which have a significant probability of transmission through sexual contact, can be contracted by either sex. Their occurrence may reflect economic and social as well as biological factors, leading to sex differences in the transmission, prevalence, and disease burden of STDs.[6]
Historically, medical research has primarily been conducted using the male body as the basis for clinical studies. The findings of these studies have often been applied across the sexes and healthcare providers have traditionally assumed a uniform approach in treating both male and female patients. More recently, medical research has started to understand the importance of taking sex into account as evidence increases that the symptoms and responses to medical treatment may be very different between sexes.[5]
Sex-related illnesses have various causes:
- Sex-linked genetic conditions
- Diseases of the reproductive system that are specific to one sex
- Social causes that relate to the gender role expected of that sex in a particular society
- Different levels of prevention, reporting, diagnosis or treatment in each gender.
Women
Examples of sex-related illnesses and disorders in female humans:[5]
- 99% of breast cancer occurs in women.[7]
- Ovarian cancer, endometriosis and other diseases of the female reproductive system occur mostly in women (except in the rare instances where other genders have said organs, such as trans men.[8])
- Females are more likely to experience severe outcomes from viral respiratory tract infections during their reproductive years, compared to males of the same age. In response to treatment, females may develop greater immune responses but may also experience more adverse reactions than males.[9][10]
- Approximately four times more women suffer from osteoporosis than men.[11]
- Autoimmune diseases, such as Sjögren's syndrome and scleroderma, are more prevalent in women. Roughly 70 percent of those living with autoimmune diseases are female.[12][13] See Sex differences in autoimmunity.
- In Western cultures, almost ten times more women than men suffer from eating disorders such as anorexia nervosa and bulimia nervosa.[14][15]
- Alzheimer's disease has a higher rate in women than in men.[16][17][18]
- About two times more women than men suffer from unipolar clinical depression (although bipolar disorder appears to affect both sexes equally).[19][20]
- About three times more women than men are diagnosed with borderline or histrionic personality disorder.[21]
- Conditions such as chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME), postural orthostatic tachycardia syndrome (POTS), fibromyalgia, irritable bowel syndrome (IBS) and idiopathic hypersomnia, which have unclear causes, are more common in women, with sex ratios ranging from 2:1 in IBS,[22] fibromyalgia[23] and idiopathic hypersomnia[24] to 4:1 in CFS[25] and 5:1 in POTS.[26]
- Most people with psychogenic non-epileptic seizures (PNES) (75%) are women.[27]
- Ataxic cerebral palsy is more common in women and girls.[28]
Men
Examples of sex-related illnesses and disorders in male humans:[5]
- Prostate cancer, testicular cancer and other diseases of the male reproductive system occur in men.[29]
- Diseases of X-linked recessive inheritance, such as colour blindness, occur more frequently in men, and haemophilia A and B occur almost exclusively in men.[30]
- The presence of a single X chromosome in males may mean that they are more susceptible to genetic diseases linked to the X chromosome,[31][32][33] such as Duchenne muscular dystrophy. hemophilia and Hunter syndrome.[34]
- The neurodegenerative diseases Parkinson's disease and Lewy body dementia are more prevalent in men.[16]
- Abdominal aortic aneurysms are six times more common in men, and thus some countries have introduced screening for males at risk of suffering the condition.[35]
- Autism is approximately four times more prevalent in males than females.[36]
- Males have increased risk of dyskinetic cerebral palsy and spastic diplegia, as well as lower limb deformities.[28]
- Schizophrenia is about 1.4 times more common in males, and on average starts two years earlier and has more severe symptoms.[37]
- More than two times more men than women are affected by antisocial personality disorder and substance use disorder.[38][39]
- Several cancers, including stomach cancer (2:1),[40] oesophageal cancer (3:1),[41] liver cancer (2:1 to 4:1)[42] and oral cancer (2:1 to 3:1),[43] which have mostly lifestyle-based risk factors, are more common in men.
- Males are more likely to experience severe outcomes from viral respiratory tract infections than women, at younger and older ages.[9]
- Tuberculosis is more common in men.[44]
- In cases of preterm birth, being male is associated with higher mortality and morbidity in terms of respiratory distress, cardiovascular disorders (specifically hypotension), neurodevelopmental disorders, and immune disorders.[45]
See also
- Andrology
- Gynaecology
- Health equity
- Men's health
- Obstetrics and gynecology
- Reproductive medicine
- Sex differences in humans
- Women's health
References
- ^ Ngo, ST; Steyn, FJ; McCombe, PA (August 2014). "Gender differences in autoimmune disease". Frontiers in Neuroendocrinology. 35 (3): 347–69. doi:10.1016/j.yfrne.2014.04.004. PMID 24793874.
- ^ Barochiner, J; Aparicio, LS; Waisman, GD (2014). "Challenges associated with peripheral arterial disease in women". Vascular Health and Risk Management. 10: 115–28. doi:10.2147/vhrm.s45181. PMC 3956880. PMID 24648743.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ a b c Oertelt-Prigione, S.; Regitz-Zagrosek, V., eds. (2012). Sex and Gender Aspects in Clinical Medicine. London, UK: Springer. ISBN 978-1447160021.
- ^ editors, Committee on Understanding the Biology of Sex and Gender Differences; Theresa M. Wizemann and Mary-Lou Pardue (2001). Exploring the biological contributions to human health : does sex matter? ([Online-Ausg.] ed.). Washington, D.C: National Academy Press. ISBN 978-0309072816.
{{cite book}}:|last1=has generic name (help)CS1 maint: multiple names: authors list (link) - ^ a b c d e Regitz‐Zagrosek, Vera (July 2012). "Sex and gender differences in health: Science & Society Series on Sex and Science". EMBO reports. 13 (7): 596–603. doi:10.1038/embor.2012.87. Retrieved 10 November 2021.
- ^ Madkan, Vandana K.; Giancola, Angela A.; Sra, Karan K.; Tyring, Stephen K. (1 March 2006). "Sex Differences in the Transmission, Prevention, and Disease Manifestations of Sexually Transmitted Diseases". Archives of Dermatology. 142 (3). doi:10.1001/archderm.142.3.365. Retrieved 10 November 2021.
- ^ "Male Breast Cancer Treatment". National Cancer Institute. 2014. Archived from the original on 4 July 2014. Retrieved 29 June 2014.
- ^ "Ovarian Cancer in Transgender Men". The National LGBT Cancer Network. Retrieved 2021-02-21.
- ^ a b Ursin, Rebecca L.; Klein, Sabra L. (29 September 2021). "Sex Differences in Respiratory Viral Pathogenesis and Treatments". Annual Review of Virology. 8 (1): 393–414. doi:10.1146/annurev-virology-091919-092720. ISSN 2327-056X. Retrieved 10 November 2021.
- ^ Klein, Sabra L.; Flanagan, Katie L. (October 2016). "Sex differences in immune responses". Nature Reviews Immunology. 16 (10): 626–638. doi:10.1038/nri.2016.90. ISSN 1474-1741. Retrieved 11 November 2021.
- ^ Khaled A. Alswat (1 Apr 2017). "Gender Disparities in Osteoporosis". Journal of Clinical Medicine Research. 9 (5): 382–387. doi:10.14740/jocmr2970w. PMC 5380170. PMID 28392857.
- ^ Rose, NR; Bona, C (September 1993). "Defining criteria for autoimmune diseases (Witebsky's postulates revisited)". Immunology Today. 14 (9): 426–30. doi:10.1016/0167-5699(93)90244-F. PMID 8216719.
- ^ Hayter, SM; Cook, MC (August 2012). "Updated assessment of the prevalence, spectrum and case definition of autoimmune disease". Autoimmunity Reviews. 11 (10): 754–65. doi:10.1016/j.autrev.2012.02.001. PMID 22387972.
- ^ Diagnostic and statistical manual of mental disorders : DSM-5 (5 ed.). Washington: American Psychiatric Publishing. 2013. pp. 338–345. ISBN 978-0-89042-555-8.
- ^ American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (Fifth ed.). Arlington, VA: American Psychiatric Publishing. pp. 345–349. ISBN 978-0-89042-555-8.
- ^ a b Zielonka, Daniel; Stawinska-Witoszynska, Barbara (2020). "Gender Differences in Non-sex Linked Disorders: Insights From Huntington's Disease". Frontiers in Neurology. 11: 571. doi:10.3389/fneur.2020.00571. ISSN 1664-2295. Retrieved 11 November 2021.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Di Carlo A, Baldereschi M, Amaducci L, Lepore V, Bracco L, Maggi S, Bonaiuto S, Perissinotto E, Scarlato G, Farchi G, Inzitari D (January 2002). "Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy. The ILSA Study". Journal of the American Geriatrics Society. 50 (1): 41–48. doi:10.1046/j.1532-5415.2002.50006.x. PMID 12028245. S2CID 22576935.
- ^ Andersen K, Launer LJ, Dewey ME, Letenneur L, Ott A, Copeland JR, et al. (December 1999). "Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies. EURODEM Incidence Research Group". Neurology. 53 (9): 1992–97. doi:10.1212/wnl.53.9.1992. PMID 10599770. S2CID 22725252.
- ^ American Psychiatric Association (2013), Diagnostic and Statistical Manual of Mental Disorders (5th ed.), Arlington: American Psychiatric Publishing, pp. 160–68, ISBN 978-0-89042-555-8, retrieved 22 July 2016
- ^ Schmitt A, Malchow B, Hasan A, Falkai P (February 2014). "The impact of environmental factors in severe psychiatric disorders". Front Neurosci. 8 (19): 19. doi:10.3389/fnins.2014.00019. PMC 3920481. PMID 24574956.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Diagnostic and statistical manual of mental disorders: DSM-5 (5th ed.). Washington [etc.]: American Psychiatric Publishing. 2013. pp. 645, 663–6. ISBN 978-0-89042-555-8.
- ^ "Definition & Facts for Irritable Bowel Syndrome | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2019-07-04.
- ^ Clauw, Daniel J. (16 April 2014). "Fibromyalgia". JAMA. 311 (15): 1547–55. doi:10.1001/jama.2014.3266. PMID 24737367.
- ^ Mallampalli, Monica P.; Carter, Christine L. (2014). "Exploring Sex and Gender Differences in Sleep Health: A Society for Women's Health Research Report". Journal of Women's Health. 23 (7): 553–562. doi:10.1089/jwh.2014.4816. ISSN 1540-9996. PMC 4089020. PMID 24956068.
- ^ "Chronic fatigue syndrome". womenshealth.gov. 21 February 2017. Retrieved 13 May 2019.
- ^ Benarroch EE (December 2012). "Postural tachycardia syndrome: a heterogeneous and multifactorial disorder". Mayo Clinic Proceedings. 87 (12): 1214–25. doi:10.1016/j.mayocp.2012.08.013. PMC 3547546. PMID 23122672.
- ^ Mellers, JD (August 2005). "The approach to patients with 'non-epileptic seizures'". Postgraduate Medical Journal. 81 (958): 498–504. doi:10.1136/pgmj.2004.029785. PMC 1743326. PMID 16085740.
- ^ a b Romeo, Domenico; Sini, Francesca; Brogna, Claudia; Albamonte, Emilio; Ricci, Daniela; Mercuri, Eugenio (2016-04-21). "Sex differences in cerebral palsy on neuromotor outcome: a critical review". Developmental Medicine & Child Neurology. 58 (8): 809–813. doi:10.1111/dmcn.13137. PMID 27098195. Retrieved 5 May 2021.
- ^ "Prostate vs. testicular cancer: Similarities and differences". Medical News Today. 25 October 2021. Retrieved 10 November 2021.
- ^ "U.S. National Library of Medicine". Archived from the original on 12 October 2007. Retrieved 2 December 2007.
- ^ Migeon, Barbara R. (June 2007). "Why females are mosaics, x-chromosome inactivation, and sex differences in disease". Gender Medicine. 4 (2): 97–105. doi:10.1016/S1550-8579(07)80024-6. Retrieved 11 November 2021.
- ^ Brown, Carolyn (September 2007). "Patchwork women". Nature Genetics. 39 (9): 1043–1043. doi:10.1038/ng0907-1043. ISSN 1546-1718. Retrieved 11 November 2021.
- ^ Migeon, Barbara R. (2014). Females are mosaics : X inactivation and sex differences in disease (Second ed.). Oxford: Oxford University Press. ISBN 9780199927531.
- ^ Doblhammer, Gabriele; Gumà, Jordi (February 12, 2018). A Demographic Perspective on Gender, Family and Health in Europe. Springer. p. 78. ISBN 978-1013269073. Retrieved 11 November 2021.
- ^ "Men to get aneurysm screening". BBC. 5 January 2008. Retrieved 6 June 2016.
- ^ Newschaffer CJ, Croen LA, Daniels J; et al. (2007). "The epidemiology of autism spectrum disorders" (PDF). Annu Rev Public Health. 28: 235–58. doi:10.1146/annurev.publhealth.28.021406.144007. PMID 17367287. Archived from the original (PDF) on 2013-09-03.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Picchioni MM, Murray RM (July 2007). "Schizophrenia". BMJ. 335 (7610): 91–95. doi:10.1136/bmj.39227.616447.BE. PMC 1914490. PMID 17626963.
- ^ Alegria, Analucia A.; Blanco, Carlos; Petry, Nancy M.; Skodol, Andrew E.; Liu, Shang-Min; Grant, Bridget; Hasin, Deborah (July 2013). "Sex differences in antisocial personality disorder: results from the National Epidemiological Survey on Alcohol and Related Conditions". Personality Disorders. 4 (3): 214–222. doi:10.1037/a0031681. ISSN 1949-2723. PMC 3767421. PMID 23544428.
- ^ Galanter, Marc; Kleber, Herbert D.; Brady, Kathleen T. (17 December 2014). The American Psychiatric Publishing Textbook of Substance Abuse Treatment. doi:10.1176/appi.books.9781615370030. ISBN 978-1-58562-472-0.
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- ^ Montgomery, EA; et al. (2014). "Oesophageal Cancer". In Stewart, BW; Wild, CP (eds.). World Cancer Report 2014. World Health Organization. pp. 528–543. ISBN 978-9283204299.
- ^ Hefaiedh R; et al. (Aug–Sep 2013). "Gender difference in patients with hepatocellular carcinoma". La Tunisie Médicale. 91 (8–9): 8–9. PMID 24227507.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Chaturvedi AK, Anderson WF, Lortet-Tieulent J, Curado MP, Ferlay J, Franceschi S, Rosenberg PS, Bray F, Gillison ML (December 2013). "Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers". Journal of Clinical Oncology. 31 (36): 4550–9. doi:10.1200/jco.2013.50.3870. PMC 3865341. PMID 24248688.
- ^ Hertz, David; Schneider, Bianca (2019). "Sex differences in tuberculosis". Seminars in Immunopathology. 41 (2): 225–237. doi:10.1007/s00281-018-0725-6. ISSN 1863-2300. PMID 30361803. S2CID 53030554. Retrieved 2021-02-21.
- ^ O'Driscoll, David N.; McGovern, Matthew; Greene, Catherine; Molloy, Eleanor (2018-05-11). "Gender disparities in preterm neonatal outcomes". Acta Paediatrica. 107 (9): 1494–1499. doi:10.1111/apa.14390. PMID 29750838. Retrieved 5 May 2021.